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Exonuclease-catalyzed recycling and annular four-footed DNA walking amplification-assisted "on-off-super on" signal transitions for photoelectrochemical biosensing of kanamycin.
Biosens Bioelectron
February 2024
Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi, 435002, China. Electronic address:
Photoelectrochemical (PEC) biosensors have exhibited a promising potential for assays of a large variety of analytes; however, how to realize their low background-based "super on" signal output is still a great challenge. Herein, we report a novel multiple nucleic acid amplification-assisted "on-off-super on" signal transition mechanism for the PEC biosensing of kanamycin antibiotics. The biosensing platform was constructed on a perylene-3,4,9,10-tetracarboxylic dianhydride-based photoelectrode, and its strong photocurrent could be well inhibited by an anchored ferrocene (Fc)-labeled hairpin DNA to produce a low background signal.
View Article and Find Full Text PDFInsulin resistance is associated with subclinical myocardial dysfunction and reduced functional capacity in heart failure with preserved ejection fraction.
J Cardiol
February 2024
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Article Synopsis
- The study examines the relationship between obesity, insulin resistance, and heart failure with preserved ejection fraction (HFpEF), highlighting that both conditions are linked to worse cardiovascular outcomes.* -
- Researchers assessed 92 HFpEF patients' insulin resistance using the estimated glucose disposal rate (eGDR) and conducted tests to evaluate myocardial function and physical capability.* -
- Findings reveal that higher insulin resistance (lower eGDR) is associated with poorer left ventricular longitudinal strain (LVLS) and reduced physical performance, even after adjusting for other factors.*
Prefab Hollow Glass Microsphere-Based Immunosensor with Liquid Crystal Sensitization for Acute Myocardial Infarction Biomarker Detection.
Biosensors (Basel)
June 2022
School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.
Quantitative detection of cardiac troponin biomarkers in blood is an important method for clinical diagnosis of acute myocardial infarction (AMI). In this work, a whispering gallery mode (WGM) microcavity immunosensor based on a prefab hollow glass microsphere (HGMS) with liquid crystal (LC) sensitization was proposed and experimentally demonstrated for label-free cardiac troponin I-C (cTnI-C) complex detection. The proposed fiber-optic immunosensor has a simple structure; the tiny modified HGMS serves as the key sensing element and the microsample reservoir simultaneously.
View Article and Find Full Text PDFEffect of a single dose of pimobendan on right ventricular and right atrial function in 11 healthy cats.
J Vet Cardiol
October 2021
Division of Cardiology, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zürich, Switzerland; Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Italy. Electronic address:
Objectives: The objective of this study was to investigate the effect of pimobendan on echocardiographic parameters of right ventricular and atrial function in healthy cats.
Animals: Eleven privately owned, healthy adult cats.
Material And Methods: Each cat underwent five echocardiographic examinations: the first and second examinations were performed 1 h apart on day 0.
Effect of Levosimendan on Ventricular Systolic and Diastolic Functions in Heart Failure Patients: A Meta-Analysis of Randomized Controlled Trials.
J Cardiovasc Pharmacol
June 2021
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Levosimendan, a calcium sensitizer, exerts inotropic action through improving left ventricular ejection fraction. We noticed that only few clinical studies are published in which the effects of levosimendan on cardiac function are studied by echocardiography. When screening the literature (PubMed, Embase, and CENTRAL, from inception to August 2020), we found 29 randomized controlled trials on levosimendan containing echocardiographic data.
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