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Neuronal Plasma Membranes as Supramolecular Assemblies for Biological Memory.

Langmuir

January 2025

Department of Physics and Astronomy, The University of Tennessee, Knoxville, Tennessee 37996, United States.

Biological memory is the ability to develop, retain, and retrieve information over time. Currently, it is widely accepted that memories are stored in synapses (i.e.

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Background: Recent studies have shown that ferroptosis, a newly identified regulated cell death characterized by increased lipid peroxidation and accumulation of toxic lipid peroxides, is closely related to the pathophysiological processes of nervous system diseases which can be inhibited with iron chelators, lipophilic antioxidants, and lipid peroxidation inhibitors.

Objective: To review the current evidence on the efficacy of various natural polyphenols in nervous system injury.

Methods: The data selected for this review were collected by searching the MEDLINE/PubMed, Web of Science, Scopus, and Google Scholar database for articles published in English between 2000 and 2024 using the following terms: cell death, regulated cell death, ferroptosis, lipid peroxides, iron, and glutathione peroxidase.

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The study evaluated the anti-hyperlipidemic effects of myrcenol and curzerene on a high fat diet induced hyperlipidemia rat model. Thirty male albino rats were fed on a high-fat diet for four months. The HFD-induced hyperperlipidemia rats were treated with rosuvastatin (10 mg/kg), curzerene (130 mg/kg) and myrcenol (100 mg/kg) for four weeks.

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Background: Serum vitamin D deficiency is intricately linked to metabolic disorders, however, evidence on its association with continuous metabolic risk in children and adolescents remains insufficient. This study aims to elucidate the relationship between serum vitamin D levels and continuous metabolic risk.

Methods: The cross-sectional analysis involved 4490 participants aged 6 ~ 18, and the longitudinal investigation included 1398 individuals aged 6 ~ 12 years.

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Purpose: To study the potential of a candidate probiotic strain belonging to the Enterococcus durans species in alleviating hypercholesterolemia and improving the microbial milieu of rat gut.

Methods: A previously isolated and characterized E. durans strain NPL 1334 was further screened in vitro for its bile salt hydrolyzation and cholesterol assimilation ability.

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