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| http://dx.doi.org/10.2105/ajph.63.5.379-a | DOI Listing |
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Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator's Consortium Registry Analysis.
JTO Clin Res Rep
January 2025
Division of Hematology & Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC.
Methods: Patients with metastatic EGFRm NSCLC who received 1L systemic therapy at sites within the Academic Thoracic Medical Investigator's Consortium were included; demographic and clinical data including treatment patterns were described.
Lung neuroendocrine neoplasms are a group of diverse, heterogeneous tumours that range from well-differentiated, low-grade neuroendocrine tumours-such as typical and atypical carcinoids-to high-grade, poorly differentiated aggressive malignancies, such as large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC). While the incidence of SCLC has decreased, the worldwide incidence of other pulmonary neuroendocrine neoplasms has been increasing over the past decades. In addition to the standard histopathological classification of lung neuroendocrine neoplasms, the introduction of molecular and sequencing techniques has led to new advances in understanding the biology of these diseases and might influence future classifications and staging that can subsequently improve management guidelines in the adjuvant or metastatic settings.
View Article and Find Full Text PDFClinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival.
Nat Med
January 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Nearly all pancreatic adenocarcinomas (PDAC) are genomically characterized by KRAS exon 2 mutations. Most patients with PDAC present with advanced disease and are treated with cytotoxic therapy. Genomic biomarkers prognostic of disease outcomes have been challenging to identify.
View Article and Find Full Text PDFPrevalence of work-related musculoskeletal disorder and ergonomic risk practice among medical laboratory professionals at health facilities of eastern Ethiopia.
Front Public Health
January 2025
School of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Background: Musculoskeletal disorders represent a significant occupational problem due to poor ergonomic workstations among medical laboratory professionals; however, there is limited information regarding ergonomic-related musculoskeletal disorders among laboratory personnel in Ethiopia, particularly in eastern Ethiopia.
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Full-Polyethylene Glenosphere Reverse Shoulder Arthroplasty: Functional outcomes and notching rate at mid-term follow-up.
Tunis Med
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Unlabelled: Introduction-Aim: Full-polyethylene glenosphere reverse shoulder arthroplasty (FP-RSA) known commonly as inverted-bearing concept utilizes a polyethylene glenosphere and metallic humeral liner. The aim was to assess mid-term outcomes of FP-RSA focusing on the incidence of scapular notching.
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