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Sci Rep
November 2023
Research Group for Implantable Microsystems, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
Physiol Rep
September 2023
Department of Pharmacology, Bolu Abant Izzet Baysal University Medical School, Bolu Merkez/Bolu, Turkey.
The aim of our study is to investigate the electrophysiological and anti-inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2-4 months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30 min after the epileptiform activity was created with penicillin injected intracortically under anesthesia.
View Article and Find Full Text PDFSci Rep
September 2023
Research Group for Implantable Microsystems, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
Infrared neuromodulation (INM) is a promising neuromodulation tool that utilizes pulsed or continuous-wave near-infrared (NIR) laser light to produce an elevation of the background temperature of the neural tissue. The INM-based cortical heating has been proven as an effective modality to induce changes in neuronal activities. In this paper, we investigate the effect of INM-based cortical heating on the characteristics of interictal epileptiform discharges (IEDs) induced by penicillin in anesthetized rats.
View Article and Find Full Text PDFEpilepsy Res
August 2023
Atatürk University, Technical Sciences Vocational College, Chemistry and Chemical Processing Technologies Department, 25240 Erzurum, Türkiye. Electronic address:
Background: Epilepsy is a nervous system disease that affects millions of individuals worldwide, and up to 25% of patients have seizures that are resistant to antiepileptic drugs. Therefore, there is a need for the discovery of tolerable, effective antiepileptic agents. This study was aimed to electrophysiologically investigate the effects of the peptide hormone adropin, which was discovered in recent years and whose expression was determined in many organs, on penicillin-induced epileptiform activity in rats.
View Article and Find Full Text PDFArq Neuropsiquiatr
December 2022
Bolu Abant İzzet Baysal University School of Medicine, Department of Pharmacology, Bolu, Turkey.
Background: The fact that inflammation triggers epileptic seizures brings to mind the antiepileptic properties of anti-inflammatory drugs.
Objective: To investigate the electrophysiological and anti-inflammatory effects of fingolimod on an experimental penicillin-induced acute epileptic seizure model in rats.
Methods: Thirty-two male Wistar rats were divided into four groups: control (penicillin), positive control (penicillin + diazepam [5 mg/kg]), drug (penicillin + fingolimod [0.
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