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Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats.
Curr Neuropharmacol
January 2025
Department of Pharmacology, School of Medicine University of Zagreb, Zagreb, Croatia.
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia, and hyperlithemia. In hyperkalemia, BPC 157 demonstrated a comprehensive counteractive effect against KCl overdose (intraperitoneally, intragastrically, and in vitro), effectively mitigating symptoms such as muscular weakness, hypertension, sphincter dysfunction, arrhythmias, and lethality. It also counteracted the adverse effects of succinylcholine and magnesium overdose, including systemic muscle paralysis, arrhythmias, and hyperkalemia.
View Article and Find Full Text PDFCluster headache and galcanezumab: the first real-world Brazilian study and an expert consensus on its use among other treatments.
J Headache Pain
December 2024
Universidade Federal do Delta do Parnaíba, Avenida São Sebastião, 2819, Fátima, Parnaíba, PI, 64001-020, Brazil.
Objective: To present the first Brazilian real-world results with galcanezumab and provide a consensus expert opinion on the prophylactic treatment of cluster headache (CH) in Brazil.
Methods: The first part of the study (real-world results) was observational, prospective, uncontrolled, and descriptive. A sample of 44 consecutive patients with episodic or chronic CH were evaluated and treated in a traditional tertiary clinic from March 2020 to June 2024.
Effect of powder air polishing and ultrasonic scaling on the marginal and internal interface (tooth-veneer) of ceramic veneers: an in vitro study.
Clin Oral Investig
November 2024
Department of Prosthodontics and Materials Science, Leipzig University, Liebigstraße 12, 04103, Leipzig, Germany.
Objectives: This study investigated the influence of prophylactic treatments and thermocycling on the marginal and internal veneering interface (tooth-veneer) as well as on the surface texture of ceramic veneers.
Materials And Methods: A total of 32 extracted human premolars were restored with veneers made of lithium disilicate (LDS) or zirconia-reinforced lithium silicate (ZLS). An artificial aging of the specimens was conducted via five cycles of both thermocycling (5/55°C) and prophylactic treatment (powder air polishing or ultrasonic scaling).
Lithium: Fifteen Years Later.
Neuropsychobiology
December 2024
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Background: The 75th anniversary of introducing lithium into modern psychiatry is recognized, attested by the 1949 paper of John Cade. About this event, my editorial in the special 2010 issue of Neuropsychobiology was titled "Lithium: Sixty Years Thereafter." Since then, fifteen more years have brought further information about lithium.
View Article and Find Full Text PDFA novel causative factor of injury: Severe burns related to fires and explosions of lithium-ion batteries of electric motorcycles.
Injury
September 2024
Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, PR China. Electronic address:
Severe burns related to fires and explosions of lithium-ion batteries of electric motorcycles have not been reported to date. We retrospectively studied 419 patients admitted to our burn intensive care unit from January 2016 to December 2021. Of these 419 patients, 26 (22 male, 4 female; median age, 42 years) had burns related to lithium-ion battery fires and explosions, and all of their injury characteristics were similar to those of traditional flame burns.
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