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Lentigo maligna (LM) can be difficult to diagnose and recurrence is not uncommon. In vivo reflectance confocal microscopy (RCM) improves diagnostic accuracy of LM. LM can be difficult to discern from coexistent metal-induced cutaneous hyperpigmentation (MICH).
View Article and Find Full Text PDFWhen self-medication goes wrong: the case of argyria at the Padua Morgagni Museum of Pathology.
Virchows Arch
June 2022
University Museums Centre CAM, University of Padua, Via A. Gabelli, 61, 35121, Padua, Italy.
A unique specimen of argyria is preserved in the Morgagni Museum of Pathological Anatomy at the University of Padua (Italy). It is a stuffed head belonging to a man who decided to cure his syphilis by himself with the so-called infernal stone (silver nitrate) every day for years, thus developing argyria in the second half of the nineteenth century. Paleopathological and historical studies were performed on the specimen to confirm the diagnosis of argyria.
View Article and Find Full Text PDFLocalized cutaneous argyria: Review of a rare clinical mimicker of melanocytic lesions.
Ann Diagn Pathol
October 2021
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address:
Localized cutaneous argyria is a rare cutaneous disorder that has been associated with occupational exposure, dental procedures, topical agents, acupuncture, earrings, and nasal piercings. In this paper, we review the current literature on localized cutaneous argyria, highlight its clinical and histologic diagnostic features, and then discuss the clinical and histological differential diagnoses for blue-gray skin and black dermal pigment, respectively. We also discuss the utility of ancillary techniques, such as deeper histologic levels, special stains, darkfield microscopy, and advanced micro-analytical techniques in helping diagnose localized cutaneous argyria.
View Article and Find Full Text PDFOccupational Localized Cutaneous Argyria With Pseudo-Ochronosis in a Jeweler.
Am J Dermatopathol
November 2021
Department of Dermatopathology, St George's University Hospital, London, United Kingdom.
A case of localized argyria in a 36-year-old female jeweler is described who presented with 2 discrete and asymptomatic bluish-black pigmented macules on the pulp of her left middle finger. A skin biopsy from both lesions demonstrated deposition of brown/black pigmented granules along the basement membrane zone of eccrine glands, blood vessels, nerves, and the dermo-epidermal junction fully in keeping with silver deposition. In addition, there was yellow-brown deposition seen within the interstitial dermis mimicking an early form of ochronosis, so called "pseudo-ochronosis.
View Article and Find Full Text PDF[Neurological patient with greyblue skin colour of unknown origin].
Dtsch Med Wochenschr
January 2021
Abteilung für Pneumologie und Infektiologie, Christliches Krankenhaus Quakenbrück GmbH, Quakenbrück.
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