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The evaluation of urinary protein patterns in a stone-forming animal model using two-dimensional polyacrylamide gel electrophoresis.
J Urol
April 1991
Division of Urology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
The exact role of urinary proteins in kidney stone formation remains an area of controversy. Some investigators believe that urinary proteins are selectively incorporated within urinary calculi and as such have an active role in stone formation. Other investigators believe that urinary proteins are nonspecifically adsorbed into urinary crystals and thus have only a passive role in stone formation.
View Article and Find Full Text PDFThe effects of diet and intranephronic calculosis on bone modeling parameters and parathyroid volumes in the rat were studied. Bone chemical analyses and histomorphometric evaluation indicated that a modified AIN diet, containing minimal required levels of calcium, phosphorus and magnesium, was not nutritionally adequate. Although the mineral content of the modified AIN diet barely met the demands for normal bone modeling, both the AIN-76TM and modified AIN diet caused intranephronic calculosis.
View Article and Find Full Text PDFThe effects of varying dietary levels of calcium, phosphorus and magnesium on the incidence and severity of intranephronic calculosis were studied. Renal calculi were induced by feeding female rats the AIN-76TM semipurified diet for 4 weeks. During this time period, dietary levels of 350, 450 or 550 mg calcium per 100 g diet did not influence the occurrence of urolithiasis.
View Article and Find Full Text PDFFemale Sprague-Dawley rats weighing 45-55 g fed a purified diet for 18 days developed hydroxyapatite intratubular lithiasis, the earliest calcific lesions being detectable by light microscopy on Day 12. The kidneys from these rats revealed ultrastructural changes in proximal tubular cells prior to intraluminal microlith formation. These changes included evidence for increased intracellular calcium, accumulation of electron-dense cytoplasmic granules, and vesiculation and shedding of brush border microvilli within Segment I of the proximal tubule.
View Article and Find Full Text PDFHistologic study of the early events in oxalate induced intranephronic calculosis.
Invest Urol
November 1979
The early phases of calcium oxalate crystal formation in rat kidneys after intraperitoneal challenge with sodium oxalate were examined. From the results we conclude that the crystals are formed intraluminally in the proximal tubules of the renal cortex. The size, number, and distribution of calcium oxalate particles depend on the amount of sodium oxalate injected and the time interval after its injection.
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