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Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents.
Antibiotics (Basel)
December 2024
Combat Wound Care Group, CRT 4, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.
: Due to rising antibiotic-resistant microorganisms, there is a pressing need to screen approved drugs for repurposing and to develop new antibiotics for controlling infections. Current in vitro and ex vivo models have mostly been unsuccessful in establishing in vivo relevance. In this study, we developed a stringent ex vivo-burned porcine skin model with high in vivo relevance to screen topical antimicrobials.
View Article and Find Full Text PDFCost Analysis of Pure Hypochlorous Acid Preserved Wound Cleanser versus Mafenide for the Irrigation of Burn Wounds.
Clinicoecon Outcomes Res
October 2024
Arizona Burn Center, Valleywise Health, Phoenix, AZ, USA.
Over 40,000 patients in the United States (US) require hospitalization for burns annually. The treatment regimen can cost more than $6,000 a day and requires the use of numerous supplies to ensure the graft takes for successful wound healing. Irrigation of the wound is a critical step for burn treatment, yet little is known about the cost-effectiveness of different irrigation modalities.
View Article and Find Full Text PDFEvaluation of pain associated with the application of burn dressings.
Int J Burns Trauma
August 2024
Brooke Army Medical Center Fort Sam Houston, Texas, USA.
Article Synopsis
- Topical wound care after burns has changed how injuries are treated by using dressings that help prevent infections and promote healing while considering factors like pain and dressing change frequency.
- This study looked at pain levels and opioid use related to different wound dressings, such as silver sulfadiazine, manuka honey, and negative-pressure wound therapy.
- Results showed silver sulfadiazine typically resulted in lower pain scores and less opioid use compared to other dressings, suggesting the need for more detailed studies to better understand their impacts on pain management.
Fighting a New Front on an Old Battlefield: Examining the Development of Topical Antimicrobial Care to Control Burn Wound Sepsis.
J Burn Care Res
January 2025
The Burn Center, MedStar Washington Hospital Center, Washington, DC 20010-2975, USA.
Recognition of invasive burn wound sepsis as a major cause of morbidity and mortality in burn-injured patients has profoundly changed the management of burn wounds and its associated complications. The development of effective topical antimicrobial therapy is one of the last major developments of modern burn care and has been driven by major world events and scientific breakthroughs. Topical antimicrobial burn care has evolved from the use of anecdotal remedies to scientific breakthroughs such as Moyer's successful dilution of silver nitrate solution, Fox's described benefit of silver sulfadiazine use in animal models, and Pruitt's dramatic improvement in post-burn mortality using topical mafenide acetate in burn wounds.
View Article and Find Full Text PDFThe Antimicrobial Efficacy of Topically Applied Mafenide Acetate, Citric Acid and Wound Irrigation Solutions Lavanox and Prontosan against .
Antibiotics (Basel)
January 2024
Institute for Research in Operative Medicine (IFOM), Cologne-Merheim Medical Center, Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany.
Since burn wound infections caused by (PA) lead to major complications and sepsis, this study evaluates the antimicrobial efficacy of the wound irrigation solutions Prontosan (PRT), Lavanox (LAV), citric acid (CA) and mafenide acetate (MA) using microbiology assays and an ex vivo skin wound model. In suspension assays, all the solutions showed significant reductions in bacterial number (log reduction: CA 5.77; LAV 4.
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