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Comparative Analysis of Methods to Induce Myocardial Infarction in a Closed-Chest Rabbit Model.
Biomed Res Int
August 2016
Université Paris Descartes, Paris, France ; INSERM U970, Paris Cardiovascular Research Center PARCC, Paris, France ; Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France.
Objective: To develop a rabbit model of closed-chest catheter-induced myocardial infarction. Background. Limitations of rodent and large animal models justify the search for clinically relevant alternatives.
View Article and Find Full Text PDFIntroduction: Many studies have demonstrated the existence of an anti-inflammatory, parasympathetic pathway, termed as the inflammatory reflex. Burn-induced heart failure has been investigated in many previous studies. Proinflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, have been shown to play a key pathogenetic role and vagus nerve stimulation attenuates proinflammatory cytokine production.
View Article and Find Full Text PDFA reliable rabbit model for hyperkinetic pulmonary hypertension.
J Thorac Cardiovasc Surg
August 2010
Department of Cardiothoracic Surgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
Objective: To study the mechanisms of vascular remodeling and increased vascular reactivity, a reliable, economic, easy, and stable animal model of hyperkinetic pulmonary hypertension is needed. The purpose of this study was to construct an animal model of hyperkinetic pulmonary arterial hypertension by chronic systemic-pulmonary shunt in young rabbits.
Methods: Thoracotomy was performed through a midsternal incision in 1-month-old rabbits, and anastomosis between the left carotid artery and pulmonary artery trunk created a chronic left-to-right shunt.
Burn-induced organ dysfunction: vagus nerve stimulation attenuates organ and serum cytokine levels.
Burns
September 2009
Department of Plastic, Hand and Reconstructive Surgery, Burn Center, Medizinische Hochschule Hannover, Germany.
Introduction: The interaction of the CNS and the immune system is well known. A parasympathetic anti-inflammatory pathway has recently been described. Both electrical and pharmacological parasympathetic stimulation attenuate proinflammatory mediator generation.
View Article and Find Full Text PDF[Semi-invasive measurement of pulmonary pressure as a method of evaluating cardiac function in hypertension and ischemic heart disease. Experience at Charité Hospital for more than 20 years].
Radiol Diagn (Berl)
July 1991
Klinik für Innere Medizin des Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
Since 1969, microcatheterization (floating catheterization) of the pulmonary artery has systematically been used at the Hospital Charité in Berlin for measuring (indirectly) the left ventricular filling pressure. That seemed especially be justified in patients in whom conventional catheterization was not needed. Noninvasive techniques had not been available.
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