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Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs.
Genes Environ
December 2024
Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, 210-9501, Japan.
Background: Previously, Japanese Environmental Mutagen and Genome Society/Mammalian Mutagenicity Study Group/Toxicogenomics Study Group (JEMS/MMS toxicogenomic study group) proposed 12 genotoxic marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2, and Tubb4b) to discriminate genotoxic hepatocarcinogens (GTHCs) from non-genotoxic hepatocarcinogens (NGTHCs) and non-genotoxic non-hepatocarcinogens (NGTNHCs) in mouse and rat liver using qPCR and RNA-Seq and confirmed in public rat toxicogenomics data, Open TG-GATEs, by principal component analysis (PCA). On the other hand, the U.S.
View Article and Find Full Text PDFIndomethacin inhibits human seasonal coronaviruses at late stages of viral replication in lung cells: Impact on virus-induced COX-2 expression.
J Virus Erad
September 2024
Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Coronaviruses (CoV), zoonotic viruses periodically emerging worldwide, represent a constant potential threat to humans. To date, seven human coronaviruses (HCoV) have been identified: HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1, globally circulating in the human population (seasonal coronaviruses, sHCoV), and three highly-pathogenic coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. Although sHCoV generally cause only mild respiratory diseases, severe complications may occur in specific populations, highlighting the need for broad-spectrum anti-coronavirus drugs.
View Article and Find Full Text PDFDimolybdenum (II,II) paddlewheel complexes bearing non-steroidal anti-inflammatory drug ligands: Insights into the chemico-physical profile and first biological assessment.
J Inorg Biochem
November 2024
Dipartimento di Farmacia, Università degli Studi "G. D'Annunzio" Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy.
Multinuclear complexes are metal compounds featured by adjacent bound metal centers that can lead to unconventional reactivity. Some ML-type paddlewheel dinuclear complexes with monoanionic bridging ligands feature promising properties, including therapeutic ones. Molybdenum has been studied for the formation of multiple-bonded M compounds due to their unique scaffold, redox, and spectroscopic properties as well as for applications in several fields including catalysis and biology.
View Article and Find Full Text PDFDifferential impacts of nonsteroidal anti-inflammatory drugs on lifespan and healthspan in aged Caenorhabditis elegans.
J Appl Toxicol
October 2024
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China.
Article Synopsis
- Aging and age-related diseases are linked to oxidative stress and inflammation, prompting research into nonsteroidal anti-inflammatory drugs (NSAIDs) for potential lifespan extension.
- In a study with Caenorhabditis elegans, aspirin and ibuprofen were found to extend lifespan in both young and old worms by reducing reactive oxygen species (ROS) and boosting antioxidant gene expression.
- Conversely, acetaminophen and indomethacin worsened aging in older worms, suggesting they may pose risks rather than benefits for elderly individuals due to increased toxicity and oxidative stress.
Targeted screening of multiple anti-inflammatory components from Flos by ligand fishing with affinity UF-LC/MS.
Front Pharmacol
April 2024
Department of Pharmacy, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, China.
Flos (CIF) has been commonly consumed for the treatment of inflammation and related skin diseases. However, the potential bioactive components responsible for its anti-inflammatory and sensitive skin (SS) improvement activities, and the correlated mechanisms of action still remain unknown. In this work, it was firstly found that the CIF extract (CIFE) displayed arrestive free radical scavenging activity on DPPH and ABTS radicals, with no significant difference with positive control Trolox ( > 0.
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