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Recent research on the potential therapeutic value of psychedelic substances has led to changes in media representation and drug policy in some U.S. states.

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The increasing economic damage caused by terrestrial gastropods, especially the Monacha cartusiana (M. cartusiana) land snail, to the agricultural sector requires a diligent and continuous search for new materials and alternatives for the control operations. In this piece of work, a magnetically separable molluscicide with high effectiveness green Barium-Cerium-Copper ferrite/TiO (Ba-Ce-CuFO/TiO) nanocomposite was greenly prepared using Eichhornia plant aqueous extract and characterized using different techniques.

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Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records.

Mol Psychiatry

January 2025

Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with their connections (edges) indicating the likelihood of one feature preceding the other. In SMD, node centrality could reveal insights into important prodromal features and potential intervention targets.

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Regulation of macrophage-mediated osteogenesis by kaempferol liposomes in trauma-induced heterotopic ossification.

Int J Pharm

January 2025

Key Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou 221006 Jiangsu, China; Department of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006 Jiangsu, China. Electronic address:

Background: Heterotopic ossification (HO) is characterized by abnormal bone formation outside the skeleton following injury or inherited disease, leading to limb dysfunction and neurological deficits. Current treatment options for HO are largely ineffective.

Methods: A network pharmacological analysis was conducted to identify the active ingredients and protein targets in Astragalus and Cinnamon Twig Five-Substance Decoction (ACTFSD) on HO.

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Speak and you shall predict: evidence that speech at initial cocaine abstinence is a biomarker of long-term drug use behavior.

Biol Psychiatry

January 2025

Psychiatry and Neuroscience Departments, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York City, NY, 10029; Psychiatry and Neuroscience Departments, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York City, NY, 10029. Electronic address:

Background: Valid scalable biomarkers for predicting longitudinal clinical outcomes in psychiatric research are crucial for optimizing intervention and prevention efforts. Here we recorded spontaneous speech from initially abstinent individuals with cocaine use disorder (iCUD) for use in predicting drug use outcomes.

Methods: At baseline, 88 iCUD provided 5-minute speech samples describing the positive consequences of quitting drug use and negative consequences of using drugs.

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