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Quantitative structure permeability relationships for phenolic compounds applied to human epidermal membranes in various solvents.
Eur J Pharm Sci
January 2025
Therapeutics Research Centre, Frazer Institute, University of Queensland, Brisbane, Australia.
Purpose: This study examined how solvent-skin-solute interactions influenced the human epidermal permeation of three similar-sized phenolic compounds applied in a series of different solvents.
Methods: Human epidermal permeation fluxes and lag times of three phenolic compounds were assessed in Franz cells for a range of solvents varying in molecular size and solubility parameters. In order to develop a mechanistic understanding of the determinants of the permeation findings, the solubility of the compounds in solvents and stratum corneum, the extent of solvent uptake by the stratum corneum and the impact of the solvents on skin hydration and transepidermal water loss were also measured.
Effects of Platelet-Rich Plasma and Concentrated Growth Factor on Viability of Ultra-Diced Cartilage Grafts in a Rabbit Model.
J Oral Maxillofac Surg
September 2024
Department of Otorhinolaryngology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
Background: Although rhinoplastic surgery has progressed considerably in recent years, nasal dorsal irregularities still cause postoperative distress for both surgeons and patients.
Purpose: The aim of this study was to measure the association between two biologic graft adjuncts, platelet-rich plasma (PRP) and concentrated growth factor (CGF), and ultra-diced cartilage viability in an animal model.
Study Design, Setting, And Sample: This study was designed as a randomized in-vivo study using a rabbit model.
Background: Osteoporosis is a systemic bone disease characterized by decreased bone density and quality, destruction of bone microstructure, and increased bone fragility. Extracellular vesicles are lipid bilayer nanoparticles that participate in intercellular communication. Extracellular vesicles are becoming popular in the study of osteoporosis and the bone cell microenvironment.
View Article and Find Full Text PDFExtracellular Vesicles in Hepatobiliary Health and Disease.
Compr Physiol
June 2023
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Extracellular vesicles (EVs) are membrane-bound nanoparticles released by cells and are an important means of intercellular communication in physiological and pathological states. We provide an overview of recent advances in the understanding of EV biogenesis, cargo selection, recipient cell effects, and key considerations in isolation and characterization techniques. Studies on the physiological role of EVs have relied on cell-based model systems due to technical limitations of studying endogenous nanoparticles in vivo .
View Article and Find Full Text PDFExosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives.
3 Biotech
March 2023
Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam 781101 India.
Exosomes are nanosized (size ~ 30-150 nm) natural vesicular structures released from cells by physiological processes or pathological circumstances. Exosomes are growing in popularity as a result of their many benefits over conventional nanovehicles, including their ability to escape homing in the liver or metabolic destruction and their lack of undesired accumulation before reaching their intended targets. Various therapeutic molecules, including nucleic acids, have been incorporated into exosomes by different techniques, many of which have shown satisfactory performance in various diseases.
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