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Efficacy of Quantra-Qplus System for Rapid Diagnosis and Treatment of Hypofibrinogenemia and Thrombocytopenia After Cardiopulmonary Bypass.
J Cardiothorac Vasc Anesth
December 2024
Department of Anesthesiology, Dokkyo Medical University Saitama Medical Center Saitama, Japan.
Objectives: To assess whether the Quantra-Qplus can provide the cutoff values for predicting transfusion thresholds after cardiopulmonary bypass.
Design: Prospective observational study.
Setting: Single-center university hospital.
Correlation of sperm motility, acrosome integrity, protamine deficiency, and DNA fragmentation in proven and unproven Friesian Holstein bulls.
J Adv Vet Anim Res
September 2024
Research Center for Applied Zoology, National Research and Innovation Agency, Bogor, Indonesia.
Article Synopsis
- This study evaluates the frozen semen quality of Friesian Holstein bulls to assess male fertility for artificial insemination, comparing proven and unproven bulls based on various scientific analyses.
- Six proven and six unproven bulls' semen was tested using advanced techniques like Computer Assisted Semen Analysis and staining methods to measure parameters like sperm motility, viability, and DNA integrity.
- Results showed no significant differences in frozen semen quality between proven and unproven bulls, indicating that both types are equally viable for breeding programs and highlighting the importance of molecular analysis in assessing semen health.
Post-Neutralisation Activated Clotting Time and Postoperative Transfusions in Cardiac Surgery Outcome.
J Coll Physicians Surg Pak
November 2024
Department of Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan.
Article Synopsis
- The study aimed to evaluate how post-protamine neutralisation activated clotting time (ACT) influences outcomes in cardiac surgery, like chest drain output, blood transfusion needs, and ICU stay.
- Conducted at The Aga Khan University Hospital from February to August 2023, it involved analyzing data from 101 elective cardiac surgery patients, split into two groups based on their ACT values.
- Results showed no significant differences in postoperative outcomes or transfusion needs between the two groups, indicating that maintaining ACT close to baseline might be beneficial without requiring aggressive treatment.
Development of a pH-Sensitive Nanoparticle via Self-Assembly of Fucoidan and Protamine for the Oral Delivery of Insulin.
Pharmaceutics
October 2024
Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Guangdong Provincial Science and Technology Innovation Center for Subtropical Fruit and Vegetable Processing, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524008, China.
: Oral insulin delivery has received much attention over the past 20 years due to its high compliance. The aim of this study is to prepare nanoparticles for the oral delivery of insulin; : Fucoidan and protamine were used to prepare a pH-sensitive nanoparticle via self-assembly. The secondary structure and in vitro stability of the nanoparticles were characterized using FTIR, XRD, ITC, and TEM.
View Article and Find Full Text PDFProtamine Dosing for Heparin Reversal after Cardiopulmonary Bypass: A Double-blinded Prospective Randomized Control Trial Comparing Two Strategies.
Anesthesiology
January 2025
Department of Anesthesiology, Perioperative Medicine, and Pain Management, University of Miami, Miller School of Medicine, Miami, Florida.
Article Synopsis
- Drug shortages, especially for medications like protamine, challenge clinical practices; conventional dosing methods may lead to excess usage and risk of harm.* -
- In a study involving cardiac surgery patients, researchers compared a fixed 250 mg dose of protamine to a ratio-based dosing method (1 mg for every 100 U heparin) for effectiveness in reversing heparin's effects.* -
- Results showed no significant difference in the effectiveness of both dosing methods, but the fixed dose resulted in significantly lower total protamine usage without increasing postoperative bleeding.*
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