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Lindl. alkaloids improve lipid metabolism by increasing LDL uptake through regulation of the LXRα/IDOL/LDLR pathway and inhibition of PCSK9 expression in HepG2 cells.
Exp Ther Med
March 2025
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563006, P.R. China.
Lindl. alkaloids (DNLA) are active ingredients that can be extracted from the traditional Chinese herb Lindl. DNLA exhibits hypoglycemic and antihyperlipidemia effects.
View Article and Find Full Text PDFPretreatment of enzymatic hydrolysis lignin based on deep eutectic solvent containing a reversibly-soluble base.
Int J Biol Macromol
January 2025
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:
The pretreatment with green deep eutectic solvents (DESs) is conducive to realizing the high-efficiency utilization of lignin at a low cost. In this study, an innovative choline chloride/urea/calcium hydroxide (ChCl/UR/Ca(OH)) DES containing a reversibly-soluble base Ca(OH) was developed for the pretreatment of enzymatic hydrolysis lignin (EHL). The lignin pretreatment effects of the proposed ChCl/UR/Ca(OH) DES were compare with a series of DESs.
View Article and Find Full Text PDFMitochondrial DNA alterations in precision oncology: Emerging roles in diagnostics and therapeutics.
Clinics (Sao Paulo)
January 2025
Centro de Investigação Translacional em Oncologia (LIM24), Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil; Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil. Electronic address:
Mitochondria are dynamic organelles essential for vital cellular functions, including ATP production, apoptosis regulation, and calcium homeostasis. Increasing research has highlighted the significance of mitochondrial DNA (mtDNA) content and alterations in the development and progression of various diseases, including cancer. The high mutation rate and vulnerability of mtDNA to damage make these alterations valuable biomarkers for cancer diagnosis, monitoring disease progression, detecting metastasis, and predicting treatment resistance across different tumor types.
View Article and Find Full Text PDFCharacterization of Rugulopteryx okamurae algae: A source of bioactive peptides, omega-3 fatty acids, and volatile compounds.
Food Chem
January 2025
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville 41013, Spain; Department of Pharmacology, Pediatrics, and Radiology, School of Medicine, University of Seville, Spain.
This study provides a detailed characterization of the invasive algae Rugulopteryx okamurae, highlighting its nutritional composition, mineral content, and potential bioactive compounds. This biomass contains 14.18 % protein, 21.
View Article and Find Full Text PDFMachine learning unveils the role of biochar application in enhancing tea yield by mitigating soil acidification in tea plantations.
Sci Total Environ
January 2025
Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. Electronic address:
Biochar, a widely utilized soil amendment in environmental applications, has been employed to enhance tea cultivation. This study utilized three machine learning models to investigate the effects of biochar on tea growth and yield, with the random forest (RF) model demonstrating superior performance (R = 0.8768, Root Mean Square Error = 6.
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