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An analytical approach to determining pethidine: An investigation of 18 patients' urine.
J Pharm Biomed Anal
October 2023
Istanbul University-Cerrahpaşa, The Institute of Forensic Sciences and Legal Medicine, Department of Science, Istanbul, Turkey. Electronic address:
Pethidine (PET) is an opioid pain-relief medicine with high addiction potential, especially among health professionals. Pethidine is commonly prescribed in Turkey as a pain-relieving medication for operative purposes. Due to its accessibility, low cost, user-friendliness, and effectiveness, PET is often misused by both healthcare professionals and patients.
View Article and Find Full Text PDFPronounced Declines in Meperidine in the US: Is the End Imminent?
Pharmacy (Basel)
November 2022
Department of Medical Education, Geisinger Commonwealth School of Medicine, Scranton, PA 18509, USA.
Background: Once a widely used analgesic in the United States (US), meperidine offered an alternative opioid to other opioids as a pain reliever and was widely assumed to be safer with acute pancreatitis. However, within the last two decades meperidine, has gone from a frequently used drug to being used only when patients exhibit atypical reactions to opioids (e.g.
View Article and Find Full Text PDFIn-sewer stability of selected analgesics and their metabolites.
Water Res
October 2021
Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, QLD 4102, Australia.
Understanding the in-sewer stability of analgesic biomarkers is important for interpreting wastewater-based epidemiology (WBE) data to estimate community-wide analgesic drugs consumption. The in-sewer stability of a suite of 19 analgesics and their metabolites was assessed using lab-scale sewer reactors. Target biomarkers were spiked into wastewater circulating in simulated gravity, rising main and control (no biofilm) sewer reactors.
View Article and Find Full Text PDFQuantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry.
Talanta
November 2021
Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Woolloongabba, QLD, 4102, Australia.
Wastewater-based epidemiology (WBE) is an established tool to analyse patterns of community drug use. In recent times, monitoring the use of analgesics has become a public health priority. An analytical method was developed, optimised and validated for a broad range of common analgesics (non-steroidal anti-inflammatories and opioids) and their metabolites at trace concentrations in wastewater influent.
View Article and Find Full Text PDFMeperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses.
BMC Vet Res
October 2020
K.L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California-Davis, CA, 95616, Davis, USA.
Background: Meperidine is a synthetic opioid that belongs to the phenylpiperidine class and is a weak mu receptor agonist. In horses there are a limited number of published studies describing the analgesic effects of systemically administered meperidine in horses. The objective of this study was to describe the pharmacokinetics, behavioral and physiologic effects and effect on thermal threshold of three doses of intravenously administered meperidine to horses.
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