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Oral Administration of [F]MC225 for Quantification of P-glycoprotein Function: A Feasibility Study.
Mol Imaging Biol
January 2025
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Purpose: This preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointestinal (GI) tract of rats using positron emission tomography (PET) following oral administration of [F]MC225. Different oral administration protocols were evaluated, and radioactivity uptake was compared with uptake following intravenous administration.
Procedures: Twelve male Wistar rats were divided into four groups and subjected to intravenous or oral [F]MC225 administration protocols: G (intravenous route), G (oral administration without fasting), G (oral administration with fasting), and G (oral administration with fasting following administration of the P-gp inhibitor tariquidar).
High-resolution national radon maps based on massive indoor measurements in the United States.
Proc Natl Acad Sci U S A
January 2025
Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02114.
Radon, a common radioactive indoor air pollutant, is the second leading cause of lung cancer in the United States. Knowledge about its distribution is essential for risk assessment and designing efficient protective regulations. However, the three current radon maps for the United States are unable to provide the up-to-date, high-resolution, and time-varying radon concentrations.
View Article and Find Full Text PDFDevelopment of a practical conversion factor for evaluating radioactivity in mixed metal and plastic clearance objects.
Appl Radiat Isot
January 2025
Tokyo City University, 1-28-1, Tamazutsumi, Setagaya-ku, Tokyo, 158-8557, Japan.
In clearance measurements involving a single material type, a conversion factor was applied to convert measurement results to activity based on an assumed uniform density. However, this factor has been found to underestimate activity in material mixtures. In this study, we proposed a method to identify the location with the lowest detection sensitivity (minimum location) in a mixture and evaluated its applicability to the conversion factor.
View Article and Find Full Text PDFIn-situ gamma-ray measurement to estimate depth distribution of Cs in farmland in Fukushima Prefecture.
J Environ Radioact
January 2025
Hama Agricultural Regeneration Research Centre, Fukushima Agricultural Technology Center, Minami-soma, Fukushima, 975-0036, Japan.
Radioactive cesium released into the atmosphere caused by the Fukushima Dai-ichi Nuclear Power Plant accident in March 2011 has contaminated the surrounding area. We confirmed the applicability of in-situ methods to evaluate the depth distribution of Cs by employing the ratio of Compton-scattering and photo-peak components (r) obtained from measured gamma-ray spectra. In the present study, we applied the in-situ method to farmlands in Fukushima Prefecture whose sites were disturbed by decontamination and plowing operations.
View Article and Find Full Text PDFDevelopment of In-Labeled Monoclonal Antibodies Targeting SFTSV Structural Proteins for Molecular Imaging of SFTS Infectious Diseases by SPECT.
Molecules
December 2024
Laboratory of Veterinary Microbiology, Joint Graduate School of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.
No effective vaccines or treatments are currently available for severe fever with thrombocytopenia syndrome (SFTS), a fatal tick-borne infectious disease caused by the SFTS virus (SFTSV). This study evaluated the potential of In-labeled anti-SFTSV antibodies targeting SFTSV structural proteins as single-photon emission computed tomography (SPECT) imaging agents for the selective visualization of SFTSV-infected sites. This study used nuclear medicine imaging to elucidate the pathology of SFTS and assess its therapeutic efficacy.
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