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Urolithiasis is a multifactorial condition where stone composition is critical in guiding treatment and prevention strategies. Advanced diagnostic techniques, such as infrared spectroscopy, provide precise stone analysis, enabling clinicians to tailor interventions based on specific stone types and associated metabolic abnormalities. Calcium oxalate monohydrate stones often require invasive approaches like percutaneous nephrolithotomy, while uric acid responds well to dissolution therapy.

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Urinothorax is a rare complication of urological procedures. This report presents a case of a patient who developed urinothorax following nephrostomy tube placement and percutaneous nephrolithotomy (PCNL). The patient was managed conservatively with chest tube and Foley catheter placement, without the need for surgery.

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More than 20 years have passed since the identification of and as causative genes for cystinuria. However, cystinuria patients exhibit significant variability in the age of lithiasis onset, recurrence, and response to treatment, suggesting the presence of modulatory factors influencing cystinuria severity. In 2016, a second renal cystine transporter, AGT1, encoded by the gene, was discovered.

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Molecular identification of missense variants in SLC3A1 gene; an approach leading to computer-aided drug design for cystinuria.

Gene

December 2023

Department of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore 54782, Pakistan. Electronic address:

Cystinuria is a rare congenital disorder characterized by the formation of cystine stones in urinary system, mainly kidneys and urinary tract. It follows the autosomal recessive inheritance pattern, where both of the parents contain the mutant allele. Cystine is an oxidized dimeric form of amino acid cysteine, shining crystal of greenish-yellow color sized greater than 5 mm.

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Rapid detection of the biomarker for cystinuria by a metal-organic framework fluorescent sensor.

Talanta

September 2023

Key Lab of Eco-Environments Related Polymer Materials of MOE; Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, PR China. Electronic address:

Arginine (Arg) is considered a valuable biomarker for various diseases, including cystinuria, and its concentration level holds significant implications for human health. To achieve the purposes of food evaluation and clinical diagnosis, it is imperative to develop a rapid and facile method for selective and sensitive determination of Arg. In this work, a novel fluorescent material (Ag/Eu/CDs@UiO-66) was synthesized by encapsulating carbon dots (CDs), Eu and Ag  into UiO-66.

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