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Synthesis, biological evaluations, and in silico assessments of phenylamino quinazolinones as tyrosinase inhibitors.
Sci Rep
January 2025
Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
A series of novel phenylamino quinazolinone derivatives were designed and synthesized as potential tyrosinase inhibitors. Among these compounds, 9r emerged as the most potent derivative, exhibiting IC values of 17.02 ± 1.
View Article and Find Full Text PDFCovalently crosslinked carboxymethyl chitosan beads containing SiO and ionic polymer for efficient adsorptive removal of methylene blue.
Int J Biol Macromol
January 2025
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, PR China. Electronic address:
The carboxymethyl chitosan (CMCS)-based porous beads are still criticized for their limited number of binding sites, which impairs their efficacy in removing aqueous pollutants. To overcome this challenge, this work introduces the production of covalently crosslinked CMCS-based beads containing SiO and poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS). The porous composite beads not only possess remarkable stability under acidic conditions, but also have abundant active binding sites for adsorption.
View Article and Find Full Text PDFInhibition of urate induced pyroptosis and reabsorption transporters overexpression in human renal tubular epithelial cells by low molecular weight fucoidan, as well as its anticoagulation and antioxidation.
Int J Biol Macromol
January 2025
College of Chemistry and Environmental Sciences, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address:
Low molecular weight fucoidan (LMWF) has been proved to be more potent than its prototype, many degradation methods have been used to prepare LMWF. This study is conducted to further explore the biological activities of LMWF prepared by ultrasound based on anticoagulation, antioxidation, and inhibition of urate induced pyroptosis and reabsorption transporters overexpression in human renal tubular epithelial cells. Data revealed that ultrasound successfully degraded fucoidan to be LMWF, the product treated for no more than 2.
View Article and Find Full Text PDFSubstrate-specific responses to mixing conditions in high-solids enzymatic hydrolysis: Insights from microcrystalline cellulose and dilute-acid pretreated corncob.
Int J Biol Macromol
January 2025
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest, Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address:
This study investigates the mixing effects on the enzymatic hydrolysis of microcrystalline cellulose (MCC) and dilute-acid pretreated corncob substrates under high-solid conditions. Enzymatic hydrolysis experiments were conducted to assess cellulose conversion rates under varying mixing conditions (0, 50, 150, and 250 rpm) and solids loadings (5 %, 15 %, 25 %, and 35 %, w/v), and distinct physicochemical properties of the substrates were characterized. Additionally, the role of mixing conditions and solid loadings on cellulose hydrolysis kinetics and enzyme adsorption on both substrates and lignin were elucidated.
View Article and Find Full Text PDFMagnetic nanoparticle modified moss Biochar: A novel solution for effective removal of enrofloxacin from aquaculture water.
J Environ Manage
January 2025
Wuxi Fisheries College, Nanjing Agricultural University, 214081, Wuxi, PR China; Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, 214081 Wuxi, PR China; Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs, 214081, Wuxi, PR China; Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, 100000, Beijing, PR China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, 214081, Wuxi, PR China. Electronic address:
The presence of residual antibiotics in water constitutes a potential threat to aquatic environments. Therefore, designing environmentally friendly and efficient biochar adsorbents is crucial. Aquaculture by-product moss (bryophyte) was transformed into biochar, which can eliminate antibiotics from wastewater through adsorption.
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