A method of testing in vivo tissue tolerance to different implant materials is presented. It aims at reduction of variance due to mechanical irritation at the tissue-implant interface through the use of cylindrical implants with grooves. The special type of histological preparation which is necessary and problems encountered when using these techniques are described. The numerical evaluation of round cells and foreign body giant cells seems to give uniform results with low variance, which could be of interest for standard testing of material.
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