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http://dx.doi.org/10.1111/j.1365-2184.1973.tb01605.xDOI Listing

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DNA synthesis inhibition and recovery in L1210 and S-180 ascites tumors following 1-beta-D-arabinofuranosylcytosine (Ara-C) and hydroxyurea (HU) were measured autoradiographically as a basis for optimizing drug schedules. Tumor bearing mice, 10(6) cells day 0, were treated on day 4 with 20, 200 or 2000 mg/kg Ara-C or 50, 300 or 1800 mg/kg HU. At various intervals following drug, [3H]thymidine was administered i.

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Material And Methods: The growth and the regression of the experimental tumor S 180 was investiaged by volume measurements and by cytophotometric studies on 50 mice in each of a pilot and in the present main experiment. In addition, histological, cytological and cytokinetic examinations were performed.

Results And Discussion: Beginning on day 18, a spontaneous regression of the tumor was found in 20% and 38% of the animals, respectively.

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