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Deciphering distinct pathogenic mechanisms of ankylosing spondylitis and systemic sclerosis via shared biomarkers ZSWIM6 and CCL3L3: Insights from an integrative bioinformatics approach.
Autoimmunity
December 2025
Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Ankylosing Spondylitis (AS) and Systemic Sclerosis (SSc) are both autoimmune diseases, albeit with distinct anatomical targets. AS primarily affects the spine and sacroiliac joints, triggering inflammation and eventual fusion of the vertebrae. SSc predominantly impacts the skin and connective tissues, leading to skin fibrosis, thickening, and potential damage to vital organs such as the lungs, heart, and kidneys.
View Article and Find Full Text PDFMaternal and fetal outcomes in those with autoimmune connective tissue disease.
Clin Rheumatol
January 2025
Division of Cardiology, University of Minnesota, Minneapolis, USA.
Article Synopsis
- Autoimmune connective tissue diseases (CTDs) such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and rheumatoid arthritis (RA) significantly impact pregnant women, leading to maternal and fetal complications.
- A retrospective study analyzed data from over 18 million deliveries and found higher odds of maternal death, acute kidney injury, and severe complications in mothers with CTDs, alongside increased risks of adverse fetal outcomes like stillbirth and preterm labor.
- The findings highlight the need for specific preconception counseling and management approaches to improve health outcomes for pregnant women with autoimmune CTDs.
Article Synopsis
- In a study of patients with systemic sclerosis (SSc), researchers examined the safety of musculoskeletal corticosteroid (MSKC) injections, focusing on the risk of scleroderma renal crisis (SRC).
- Out of 136 SSc patients, 46 received a total of 330 MSKC injections with no significant changes in vital signs, kidney function, or other health markers observed before and after the injections.
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Endothelin Inhibitors in Chronic Kidney Disease: New Treatment Prospects.
J Clin Med
October 2024
Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-367 Wrocław, Poland.
The endothelin system is reported to play a significant role in glomerular and tubulointerstitial kidney disease. In the kidney, endothelins are produced in mesangial cells and the glomerular basement membrane by the endothelium and podocytes. The endothelin system regulates glomerular function by inducing proliferation, increasing permeability and in effect proteinuria, and stimulating inflammation, tubular fibrosis, and glomerular scarring.
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