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Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturing. Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies. The neural circuits through which these emerging therapeutics modulate feeding behavior remain undefined, particularly in comparison to established peptide-based GLP1RAs.
View Article and Find Full Text PDF3D printed cacao-based formulations as nutrient carriers for immune system enhancement.
Curr Res Food Sci
December 2024
School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Article Synopsis
- This study investigates using raw Greek honey in cacao-based materials for 3D printing, focusing on their physical properties and thermal stability.
- It finds that incorporating honey not only improves the nutritional value and taste but also enhances the delivery of Vitamin D3, which is known to support the immune system but is difficult to absorb.
- The research suggests that a 10% concentration of Lavender Honey is optimal for creating a stable and effective 3D-printed product, indicating the potential for these formulations in personalized health supplements and medicine.
Pediatric Prescribers' Knowledge of the Ew Meds List and Taste Masking.
J Pediatr Pharmacol Ther
December 2024
School of Pharmacy (DEP, JAM, AKH), University of Maryland, Baltimore, MD.
Objective: The primary objective of this study was to determine pediatric prescribers' knowledge and confidence in identifying bad tasting liquid medications. The secondary objective examined the techniques used to mask the taste of liquid medications and whether any of the masking techniques recommended by prescribers were reported to be effective in children.
Methods: Nationally, health care prescribers were invited to participate in an online survey about medication tastes and masking practices.
How sugar types and fabrication methods affect palatability in paediatric-friendly oromucosal pullulan films of chlorpromazine hydrochloride.
Carbohydr Polym
January 2025
Department of Pharmacy, Division of Pharmaceutical Technology, Aristotle University of Thessaloniki, Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Thessaloniki, Greece. Electronic address:
Ensuring children adhere to their prescribed medication can be challenging, particularly when a large number of medicines on the market consist of unpalatable drugs and difficult to swallow dosage forms. Sugar-based oromucosal films are easy to administer dosage forms across all age groups within the paediatric population, as they eliminate the need for swallowing or water intake and can contribute to enhancing palatability and medicine adherence. In the current study, electrospun and 3D printed oromucosal films of chlorpromazine hydrochloride (CHZ), a bitter drug, were developed based on pullulan, a natural polysaccharide, and an array of sweeteners.
View Article and Find Full Text PDFRegional differences in diagnosis and management of cow's milk allergy.
Clin Exp Pediatr
November 2024
Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Belgium.
Background: Various guidelines for the diagnosis and management of cow's milk allergy (CMA) have been published.
Purpose: This study aimed to compare voting outcomes of experts from Mexico, the Middle East, and the European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) on statements regarding CMA.
Methods: The 3 expert groups voted on the same 10 statements.
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