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Comparison of Extrapyramidal Symptoms Among Outpatients With Schizophrenia on Long-Acting Injectable Antipsychotics.
J Clin Psychopharmacol
September 2022
From the Schizophrenia Recovery Program, The Royal Ottawa Mental Health Centre.
Background: Extrapyramidal symptoms (EPSs) are adverse effects of antipsychotics. Different risks of EPSs have been attributed to the 3 classes of antipsychotics. This study aimed to assess EPS in a clinical sample of schizophrenia patients who are on LAI and compare the severity of EPSs among the following 3 antipsychotic groups: (1) partial agonist, (2) second-generation antipsychotics, and (3) first-generation antipsychotics.
View Article and Find Full Text PDFDear Editor, The costs of antipsychotic drugs (APDs) used in the treatment of mental disorders with psychosis are mentioned in treatment guidelines (APA 2021, NICE 2014). While the American Psychiatric Association guideline states that every specialist should make decisions according to the rules and conditions of their country and their region, the National Institute of Health and Clinical Excellence guideline emphasizes that drug costs must be taken into consideration in the treatment process. Classical or first-generation antipsychotic drugs (FAPDs) are relatively cheaper in terms of sales prices compared to atypical or second-generation antipsychotic drugs (SAPDs) with a slightly different effect mechanism.
View Article and Find Full Text PDFFactors associated with dropout at 2 years post-initiation of treatment in the first episode of schizophrenia.
S Afr J Psychiatr
March 2021
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Background: Prevention of new episodes during the first 2 years after a first episode of schizophrenia (FES) may delay treatment refractoriness and brain morphological changes over time. However, adherence to treatment is characteristically poor in these patients.
Aim: The aim of this study was to examine clinical and sociodemographic factors associated with patient dropout in patients with FES.
Benefit of small dose antidepressants for functional dyspepsia: Experience from a tertiary center in eastern China.
Medicine (Baltimore)
October 2019
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou.
Background: Traditional treatment of functional dyspepsia (FD) is unsatisfactory in a subgroup of patients with FD, and the potential role of antidepressant medications also has not been definitely clarified. To provide more evidence for future optimal practice recommendations, we reviewed a 1-year clinical database of antidepressant agents applied in outpatients with FD.
Methods: Clinical presentations, treatment course, and outcomes were determined by chart review of patients referring to the functional gastrointestinal disorders specialist clinic.
[Prescription of psychotropic drugs for schizophrenic outpatients in Hungary].
Neuropsychopharmacol Hung
March 2005
Központi Honvédkórház Pszichátriai Osztály, Budapest.
Unlabelled: The complexity of the acute and maintenance pharmacological interventions is a very important problem in the management of the schizophrenic patients. Antipsychotics are used as target therapy while anxiolytics, hypnotics, antidepressants, mood stabilizers can be given as adjunctive treatment. We have evidence based, experimental, anecdotal knowledge about the therapy of schizophrenia but we do not know the facts of the practice.
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