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Hemofiltration system for the post traumatic treatment of hyperkalemia in austere conditions.
Artif Organs
December 2024
TDA Research, Inc., Wheat Ridge, Colorado, USA.
Background: Hyperkalemia, the buildup of serum potassium to levels >6 mEq L, has been a recognized complication of combat injuries such as acute kidney injury since World War II. Currently, renal replacement therapy (RRT) serves as the standard of care for hyperkalemic patients who fail to respond to medical management. However, RRT is difficult to administer in combat settings, and the time between evacuation and RRT is critical in preventing post-traumatic hyperkalemia.
View Article and Find Full Text PDFIncidence of hypoglycemia in hyperkalemia patients after treatment with insulin and dextrose in the emergency department of a tertiary care hospital in India: a prospective observational study.
Acute Crit Care
November 2024
Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
Background: Hypoglycemia is a serious, often overlooked complication of treating hyperkalemia with insulin and dextrose. If not recognized and managed, it can increase morbidity and mortality. This study aimed to estimate the incidence of hypoglycemia in hyperkalemic patients treated with 10 units of intravenous insulin, 50 ml of 50% dextrose, 10 ml of 10% calcium gluconate, and salbutamol nebulization.
View Article and Find Full Text PDFRisk of developing hyperkalemia in patients with hypertension treated with combination antihypertensive therapy - a retrospective register-based study.
Hypertens Res
January 2025
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
The risk of hyperkalemia in relation to different combinations of antihypertensive therapy remains to be elucidated. In this Danish register-based study, we aimed to investigate the risk of developing hyperkalemia in relation to different combinations of antihypertensive therapy. Using incidence density matching, we matched a hyperkalemic patient to five normokalemic patients on eGFR groups, age, sex, and time between study entry and date of potassium measurement.
View Article and Find Full Text PDFUnderstanding renal tubular acidosis.
Br J Hosp Med (Lond)
October 2024
Monash Rural Health Mildura, Monash University, Melbourne, Australia.
Article Synopsis
- Renal tubular acidosis is a metabolic disorder characterized by acidosis, hyperchloraemia, a normal anion gap, and potassium imbalances due to dysfunctional renal tubule transport proteins or enzymes.
- Genetic factors, medications, or other acquired disorders can lead to types of renal tubular acidosis, including proximal (type 2) and distal (type 1), both associated with low potassium levels, which can cause serious health issues if unresolved.
- The condition can result in long-term complications like growth issues, bone diseases, and kidney stones, and may indicate more serious underlying health problems, emphasizing the need for early diagnosis and treatment.
Manual flagging failed to identify pseudohyperkalemia in acute myeloid leukemia: case report.
Int J Emerg Med
October 2024
Division of Nephrology, Department of Internal Medicine, UCSF Fresno Center for Medical Education and Research, 155 N Fresno St, Fresno, CA, 93701, USA.
Article Synopsis
- Pseudohyperkalemia, often seen in chronic lymphocytic leukemia, is rare in acute myeloid leukemia (AML), but can pose diagnostic challenges, as shown in a case involving a 55-year-old man with severe leukocytosis and falsely elevated potassium levels.
- Despite the lab's manual flagging system meant to identify such cases, it failed to function properly, leading to reliance on clinicians' instincts for the correct diagnosis of pseudohyperkalemia.
- The incident was linked to pneumatic tube transport of blood samples, prompting the lab to consider enhancements in its flagging system and the importance of using whole blood for potassium measurements in cases of significant leukocytosis.
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