Two types of slowly adapting mechanosensitive units were revealed in the parenchyma of the rat mammary gland (SAI and SAII). At constant mechanical displacement of the parenchyma surface SAI exhibited irregular and SAII--regular firing. The diameter of the receptive fields of the SAI and SAII was 1.0--1.5 mm with the central point of this area being the most sensitive. Trapezoidal stimuli elicited both dynamic and static responses proportional to the velocity of the movement and its displacement amplitude; the threshold of the SAI and SAII increased as stimuli of increasing velocity were used.
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J Neurosci
May 2023
Neuroscience Research Australia, Sydney, New South Wales 2031, Australia.
Dexterous object manipulation depends critically on information about forces normal and tangential to the fingerpads, and also on torque associated with object orientation at grip surfaces. We investigated how torque information is encoded by human tactile afferents in the fingerpads and compared them to 97 afferents recorded in monkeys ( = 3; 2 females) in our previous study. Human data included slowly-adapting Type-II (SA-II) afferents, which are absent in the glabrous skin of monkeys.
View Article and Find Full Text PDFPLoS One
January 2018
Department of Electrical and Mechanical Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, Japan.
The feeling of touch is an essential human sensation. Four types of mechanoreceptors (i.e.
View Article and Find Full Text PDFJ Neurophysiol
October 2017
Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada
Single unit microneurography was used to record the firing characteristics of the four classes of foot sole cutaneous afferents [fast and slowly adapting type I and II (FAI, FAII, SAI, and SAII)] in response to sinusoidal vibratory stimuli. Frequency (3-250 Hz) and amplitude (0.001-2 mm) combinations were applied to afferent receptive fields through a 6-mm diameter probe.
View Article and Find Full Text PDFJ Virol Methods
September 2016
Sección Genética Evolutiva, Instituto de Biología, Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay. Electronic address:
Infectious bronchitis virus (Gammacoronavirus, Coronaviridae) is a genetically variable RNA virus (27.6kb) that causes one of the most persistent respiratory disease in poultry. The virus is classified in genotypes with different epidemiological relevance and clinical implications.
View Article and Find Full Text PDFChem Res Toxicol
April 2016
Department of Biochemistry, Faculty of Science, Charles University in Prague, Albertov 2030, 128 43 Prague 2, Czech Republic.
Eukaryotic cytochromes P450 (P450) are membrane-bound enzymes oxidizing a broad spectrum of hydrophobic substrates, including xenobiotics. Protein-protein interactions play a critical role in this process. In particular, the formation of transient complexes of P450 with another protein of the endoplasmic reticulum membrane, cytochrome b5 (cyt b5), dictates catalytic activities of several P450s.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!