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Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension.
J Cardiovasc Transl Res
August 2020
Department of Medicine, Ohio State University, Columbus, OH, USA.
Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients.
View Article and Find Full Text PDFPulmonary microvascular dysfunction and pathological changes induced by blast injury in a rabbit model.
Ulus Travma Acil Cerrahi Derg
September 2016
The 6th Department of Research Institute of Field Surgery and Daping Hospital, Third Military Medical University, Chongqing, 400042, PR China, State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, 400042, PR China.
Background: Vascular leakage has been proven to play a critical role in the incidence and development of explosive pulmonary barotrauma. Quantitatively investigated in the present study was the severity of vascular leakage in a gradient blast injury series, as well as ultrastructural evidence relating to pulmonary vascular leakage.
Methods: One hundred adult male New Zealand white rabbits were randomly divided into 5 groups according to distance from the detonator (10 cm, 15 cm, 20 cm, 30 cm, and sham control).
Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and Ser, provides a convenient way to expand protein size and, consequently, retard renal filtration. Humanized αHER2 and αCD20 Fabs were systematically fused with 100 to 600 PAS residues and produced in E.
View Article and Find Full Text PDFCalculated plasma volume status and prognosis in chronic heart failure.
Eur J Heart Fail
January 2015
University College London Hospital NHS Trust, London, UK.
Aims: Plasma volume (PV) expansion hallmarks worsening chronic heart failure (CHF) but no non-invasive means of quantifying volume status exists. Because weight and haematocrit are related to PV, they can be used to calculate relative PV status (PVS). We tested the validity and prognostic utility of calculated PVS in CHF patients.
View Article and Find Full Text PDFAlbumin adsorption onto surfaces of urine collection and analysis containers.
Clin Chim Acta
April 2014
Virginia Commonwealth University, Department of Pathology, Richmond, VA, United States. Electronic address:
Background: Adsorption of albumin onto urine collection and analysis containers may cause falsely low concentrations.
Methods: We added (125)I-labeled human serum albumin to urine and to phosphate buffered solutions, incubated them with 22 plastic container materials and measured adsorption by liquid scintillation counting.
Results: Adsorption of urine albumin (UA) at 5-6 mg/l was <0.
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