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Chermesins I-N: Bioactive spiromeroterpenoids from the marine-sourced fungus Penicillium chermesinum AS-400.

Phytochemistry

January 2025

CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Wenhai Road 1, Qingdao 266237, China; University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China. Electronic address:

Six previously undescribed spiromeroterpenoids, chermesins I-N (1-6), were isolated and identified from the marine-sourced fungus Penicillium chermesinum AS-400. Their structures were determined by nuclear magnetic resonance and mass spectroscopic data, and the relative and absolute configurations were confirmed based on nuclear Overhauser effect spectroscopic experiments, electronic circular dichroism (ECD) calculations and X-ray crystallographic analysis, and by comparisons of ECD Cotton effects with those of known congeners as well. Structurally, compound 1 represents the first example of spiromeroterpenoid demethylated at C-4.

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Polystyrene microplastics exhibit toxic effects on the widespread coral symbiotic Cladocopium goreaui.

Environ Res

January 2025

Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, School of Marine Sciences, Guangxi University, Nanning, 530004, China.

Within the coral reef habitat, members of the Symbiodiniaceae family stand as pivotal symbionts for reef-building corals. However, the physiological response of Symbiodiniaceae on microplastics are still poorly understood. Research conducted in this investigation assessed the harmful impact of polystyrene microparticles (PS-MPs) on Cladocopium goreaui, a Symbiodiniaceae species with a broad distribution.

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Eco-friendly synthesis of CuO/g-C₃N₄/Fe₃O₄ nanocomposites for efficient magnetic micro-solid phase extraction (M-μ-SPE) of trace cadmium from food and water samples.

Food Chem

December 2024

Department of Chemistry, Faculty of Sciences, Erciyes University, Kayseri, Turkiye; Technology Research and Application Center (TAUM), Erciyes University, Kayseri, Turkiye; Turkish Academy of Sciences (TUBA), Cankaya, Ankara, Turkiye; Khazar University Nano BioAnalytical Chemistry Center (NBAC), Mahsati Str 41, AZ-1096 Baku, Azerbaijan.

In this study, a green synthesis method for synthesizing a novel nanocomposite (CuO/g-C₃N₄/Fe₃O₄) utilizing renewable dragon fruit peels as the primary raw material was developed. Hydrothermal and thermal decomposition techniques were used for nanocomposite synthesis. This nanocomposite was subsequently employed for the separation and preconcentration of Cd(II) from various environments, including food and water samples.

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Enhancing the decomposition rate of ammonium perchlorate (AP), the most common oxidizer in solid propellants, is important for improving propellant performance. Metal organic frameworks (MOFs) have been developed as key materials for catalyzing AP decomposition, as they can achieve good dispersion of active sites through in-situ decomposition. Despite having considerable potential, the structural transformation process and catalytic performance of MOFs in AP decomposition are still unclear, which seriously hinders their application in the field of AP decomposition.

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Hypo-osmotic stress shifts transcription of circadian genes.

Biophys J

January 2025

Dept. of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Rd. Worcester, MA 01609. Electronic address:

Cells respond to hypo-osmotic stress by initial swelling followed by intracellular increases in the number of osmolytes and initiation of gene transcription that allow cells to adapt to the stress. Here, we have studied the genes that change expression under mild hypo-osmotic stress for 12 and 24 hours in rat cultured smooth muscle cells (WKO-3M22). We find shifts in the transcription of many genes, several of which are associated with circadian rhythm, such as per1, nr1d1, per2, dbp, and Ciart.

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