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Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model.
Narra J
December 2024
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Indonesia.
Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis.
View Article and Find Full Text PDFAssessment of Iron Metabolism and Inflammation in Children with Cerebral Palsy.
J Clin Med
December 2024
Department of Physiology, Faculty of Medicine, Mardin Artuklu University, Mardin 47100, Turkey.
Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP.
View Article and Find Full Text PDFIron Deficiency Anemia in Children During and After PICU Stay: Single-Center Retrospective Cohort, 2021-2022.
Pediatr Crit Care Med
January 2025
Center for Iron Disorders, Department of Medicine, UCLA, Los Angeles, CA.
Objectives: The primary objective was to determine iron deficiency (ID) anemia (IDA) monitoring practices in children during PICU stay. A secondary objective was to determine the current follow-up practices for IDA after PICU discharge.
Design: Retrospective observational study of 2 years (2021-2022).
The Efficacy and Safety of Roxadustat for Anemia in Hemodialysis Patients with Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials.
Toxics
November 2024
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
Background: Patients undergoing hemodialysis (HD) for chronic kidney disease (CKD) often encounter anemia. Roxadustat has not only undergone phase II-III clinical trials in patients suffering from CKD and undergoing HD; a number of post-marketing clinical studies have been conducted using the drug. This article was to assess the effectiveness and safety of roxadustat in managing anemia among patients with CKD undergoing HD.
View Article and Find Full Text PDFIron Status and Risk of Periodontitis and Dental Caries: A Mendelian Randomization Study.
Int Dent J
December 2024
Department of Prosthodontics, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, China; Institute of Stomatology, Southwest Medical University, Luzhou, China. Electronic address:
Background: Previous studies have indicated a potential relationship between iron status and oral health outcomes, specifically periodontitis and dental caries. This study employed Mendelian randomization (MR) to investigate the causal effects of iron status on these oral health conditions. The focus of this study was on key iron biomarkers, namely serum iron, ferritin, transferrin saturation (TSAT), and total iron-binding capacity (TIBC).
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