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Follow-up biopsies with microvascular inflammation and persistent donor specific antibodies identify ongoing rejection in pediatric kidney transplant recipients.
Pediatr Nephrol
January 2025
Department of Pediatrics, University of California San Diego, 3020 Children's Way MC 5137, San Diego, CA, 92123, USA.
Background: Inadequate treatment of acute rejection (AR) in pediatric kidney transplant recipients (KTR) can contribute to early allograft failure. Serum creatinine is an insensitive marker of allograft function, especially in the pediatric population, and may not detect ongoing rejection after treatment. We evaluated the utility of follow-up biopsies to detect persistent inflammation and future episodes of rejection.
View Article and Find Full Text PDFTrajectories of general and central obesity beyond middle age in relation to late-life cognitive decline and dementia.
Obesity (Silver Spring)
February 2025
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Objective: The objective was to evaluate the longitudinal patterns of central and general obesity, identify their genetic and behavioral risk determinants, and investigate the association of distinct obesity trajectories beyond middle age with subsequent cognitive decline and the risk of developing dementia in late life.
Methods: Using a nationally representative, longitudinal, community-based cohort, we examined trajectory patterns of obesity over a 14-year span beyond middle age employing latent mixture modeling. We then evaluated their relationship with subsequent cognitive decline through linear mixed models and with the risk of developing dementia using Cox models, adjusting for confounding variables.
Investigating the influence of blood meal sources on the composition of culturable haemolytic gut bacteria of a wild-caught BTV vector Culicoides oxystoma Kieffer (Diptera: Ceratopogonidae).
Med Vet Entomol
January 2025
Entomology Research Unit, Department of Zoology, The University of Burdwan, Burdwan, India.
Culicoides oxystoma Kieffer (Diptera: Ceratopogonidae) transmits many pathogens, including seven viruses, four protozoa and one nematode. This species has a wide distribution range across northern Afro-tropical, Palearctic, Australian, Indo-Malayan realms with a broad host spectrum, including cattle, buffaloes, sheep, pigs, dogs, horses and even humans. The heterogeneous nature of Culicoides' blood-feeding patterns is well documented, but the influence of various host blood meal sources on gut bacterial composition remains scant.
View Article and Find Full Text PDFRisk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database.
Front Public Health
January 2025
Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background And Aim: Changes in cognitive function are commonly associated with aging in patients with cardiovascular diseases. The objective of this research was to construct and validate a nomogram-based predictive model for the identification of cognitive impairment in older people suffering from cardiovascular diseases.
Methods And Results: This retrospective study included 498 participants with cardiovascular diseases aged >60 selected from the NHANES 2011-2014.
Preoperative predictive factors of cystobiliary fistulas in liver hydatid cysts: results of a monocentric study.
Future Sci OA
December 2025
Department of General and Digestive Surgery, Farhat Hached University Hospital - Sousse, Sousse, Tunisia.
Introduction: The evolution of hepatic hydatid cyst can be enameled with complications, mainly biliary fistula, which can be both symptomatic or occult. The aim of this study is to identify the predictive factors of occult cysto-biliary communication.
Material And Methods: This is a retrospective study of patients operated-on for uncomplicated hepatic hydatid cyst in Farhat Hached Hospital of Sousse over a period of 10 years.
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