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A self-expandable nitinol frame for cable-driven parallel mechanisms in minimally invasive cardiovascular interventions.
J Mech Behav Biomed Mater
January 2025
Department of Biomedical Engineering, Toronto Metropolitan University, Toronto, Canada; Sunnybrook Research Institute, Toronto, Canada.
The integration of self-expandable nitinol frames with cable-driven parallel mechanisms offers a promising advancement in minimally invasive cardiovascular interventions. This study presents the design, fabrication, and verification of a miniaturized self-expandable nitinol frame to enhance catheter tip steerability and navigation within complex vascular anatomies. The frame is reduced in size for delivery through 7-8 Fr sheaths while accommodating diverse vascular diameters, allowing up to a maximum expansion of 15 mm.
View Article and Find Full Text PDFThe anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028.
NPJ Sci Food
January 2025
Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, PR China.
As a form of skin cancer, melanoma's incidence rate is continuing to rise globally. Therefore, there is an urgent need to find new agents to improve survival in melanoma patients. Isoflavones, a class of phytoestrogens, are primarily found in soy and other legumes.
View Article and Find Full Text PDFHigh-coverage whole-genome sequencing of a Jakun individual from the "Orang Asli" Proto-Malay subtribe from Peninsular Malaysia.
Hum Genome Var
January 2025
Faculty of Medicine and Health Sciences, UCSI University, Negeri Sembilan, Federal Territory of Kuala Lumpur, Malaysia.
Jakun, a Proto-Malay subtribe from Peninsular Malaysia, is believed to have inhabited the Malay Archipelago during the period of agricultural expansion approximately 4 thousand years ago (kya). However, their genetic structure and population history remain inconclusive. In this study, we report the genome structure of a Jakun female, based on whole-genome sequencing, which yielded an average coverage of 35.
View Article and Find Full Text PDF[Tuberculosis Profile in Chile: Effect of Migration, Overcrowding and Income on Tuberculosis and Its Spatial Distribution].
Rev Med Chil
July 2024
Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile.
Aim: To analyze tuberculosis (TB) incidence, demographic profiles, and associated risk factors in migrant and national populations, in order to understand the impact of migration, overcrowding, and socioeconomic factors on TB prevalence and care-seeking behaviors.
Material And Methods: Data from various communes within the Metropolitan Region and other parts of the national territory were analyzed to assess TB incidence, demographic characteristics, and care-seeking behaviors among migrant and national populations.
Results: TB disproportionately affects males in both migrant and national populations.
A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan.
Sci Rep
January 2025
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Extramammary Paget disease (EMPD) is a rare skin cancer that typically occurs in the anogenital area of older people. Since efficacy of treatments for metastatic or unresectable EMPD remains poor, development of a novel therapeutic approach is strongly desired. However, the lack of EMPD models has hampered investigation of EMPD.
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