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Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure.
Sci Rep
January 2025
ArrayXpress, Inc., Raleigh, NC, USA.
Cancers of the mesothelium, such as malignant mesothelioma (MM), historically have been attributed solely to exposure to asbestos. Recent large scale genetic and genomic functional studies now show that approximately 20% of all human mesotheliomas are causally linked to highly penetrant inherited (germline) pathogenic mutations in numerous cancer related genes. The rarity of these mutations in humans makes it difficult to perform statistically conclusive genetic studies to understand their biological effects.
View Article and Find Full Text PDFFactors underlying the association between , subspecies infection and colorectal cancer: a mini review.
Gut Microbiome (Camb)
November 2024
Department of Hospital Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Article Synopsis
- Sgg is a gram-positive bacterium linked to infective endocarditis and colorectal cancer (CRC), thriving in the colorectal tumor environment.
- It has specialized features like pili for cell adhesion, bile salt hydrolase, and gallocin that help it grow in the bile-rich conditions typical of colorectal tumors.
- Sgg also affects oncogenic pathways, particularly the Wnt/β-catenin signaling, and promotes CRC progression by utilizing tumor metabolites and inducing harmful biotransformation in cancer cells.
Human Exposure to Asbestos in Central Asian Countries and Health Effects: A Narrative Review.
Med Lav
December 2024
Department of Health Sciences; Course of Research Doctorate in Public Health Sciences, University of Milan, Milan, Italy/Occupational Health Unit, Santi Paolo e Carlo Hospital, Milan, Italy.
The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late 19th and early 20th centuries. Despite efforts to ban its use, asbestos continues to be mined and used in Central Asia (as well as in Russia, China, and other countries). To gain a deeper understanding of the situation in Central Asia, we have conducted a systematic review of scientific literature on the use of asbestos, exposure assessment, and health consequences of asbestos exposure in this geographic area.
View Article and Find Full Text PDFSerum cytokines as a biomarker for immune checkpoint inhibitor toxicity in patients with pleural mesothelioma.
Front Immunol
December 2024
Department of Oncology, Oslo University Hospital, Oslo, Norway.
Background: Pleural mesothelioma (PM) is a rare cancer with a dismal prognosis. Dual immune checkpoint inhibitors have improved overall survival, but the rate of immune-related adverse events (irAEs) is high. Serum cytokines reflect systemic immune reactions and may serve as biomarkers for irAEs.
View Article and Find Full Text PDFRadiofrequency Ablation of Toxic Thyroid Nodules: An Early Experience of a Single Institution in the United States.
Endocr Pract
December 2024
Department of Surgery, New York Presbyterian Hospital - Columbia University, New York, New York. Electronic address:
Objective: The field of endocrine surgery has been expanding its minimally invasive techniques to treat a wide range of thyroid pathologies. Radiofrequency ablation (RFA) is one targeted thermal therapy that has been identified as safe and effective for the treatment of benign pathologies as an alternative to surgery. We have employed RFA at our institution and are reporting our experience with this techniques safety, efficacy, and considerations in the treatment of toxic adenomas and multinodular goiters.
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