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Rapid synthesis of manganese dioxide nanoparticles for enhanced biocompatibility and theranostic applications.
RSC Adv
January 2025
College of Chemistry and Chemical Engineering, Lingnan Normal University Zhanjiang 524048 China
Manganese dioxide (MnO), lauded for its biocompatibility and distinctive optical and physical characteristics, has become an indispensable material in the biomedical field, showing immense potential in disease detection, treatment, and prevention. Particularly, the ability of MnO nanoparticles to oxidize glutathione (GSH) to its oxidized form has positioned them as pivotal players in GSH sensing. However, conventional preparation methods, whether top-down or bottom-up, often result in nanoparticles that require multi-step processing and modification to achieve good dispersion in physiological conditions, which is both time-consuming and complex.
View Article and Find Full Text PDF"Minimal-Advice" on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients.
High Blood Press Cardiovasc Prev
January 2025
Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Via S. Pansini, 5, 80131, Naples, Italy.
Introduction: A strong and well-known association exists between salt consumption, potassium intake, and cardiovascular diseases. MINISAL-SIIA results showed high salt and low potassium consumption in Italian hypertensive patients. In addition, a recent Italian survey showed that the degree of knowledge and behaviour about salt was directly interrelated, suggesting a key role of the educational approach.
View Article and Find Full Text PDFDownmodulation of potassium conductances induces epileptic seizures in cortical network models via multiple synergistic factors.
J Neurosci
January 2025
Department of Neuroscience, Brown University, Providence RI, USA.
Voltage-gated potassium conductances [Formula: see text] play a critical role not only in normal neural function, but also in many neurological disorders and related therapeutic interventions. In particular, in an important animal model of epileptic seizures, 4-aminopyridine (4-AP) administration is thought to induce seizures by reducing [Formula: see text] in cortex and other brain areas. Interestingly, 4-AP has also been useful in the treatment of neurological disorders such as multiple sclerosis (MS) and spinal cord injury, where it is thought to improve action potential propagation in axonal fibers.
View Article and Find Full Text PDFA new in situ fracturing-enhanced oxidative remediation for various low-permeability phenanthrene-contaminated soils: Oxidation effectiveness and kinetics of potassium permanganate.
J Hazard Mater
January 2025
Department of Geotechnical Engineering, Tongji University, Shanghai 200092, China; Key Laboratory of Geotechnical and Underground Engineering of the Ministry of Education, Shanghai 200092, China.
A new in situ fracturing-enhanced oxidative remediation approach was recommended in this study to achieve rapid and efficient remediation of low-permeability contaminated sites. The objective of this study was to evaluate the effects of permeability and potassium permanganate (KMnO) concentration on the oxidation effectiveness and kinetics of KMnO in phenanthrene (PHE)-contaminated soil through rigid-wall hydraulic conductivity tests and a series of laboratory experiments. The results indicate that for various low-permeability contaminated soils, there was a critical KMnO concentration to significantly reduce the remediation time and a critical Darcy velocity to meet remediation goals.
View Article and Find Full Text PDFEffect of a modified methyl methacrylate-p-styrene sulfonic acid copolymer-based gel desensitizer on dentin permeability and tubule occlusion in human dentin .
J Dent Sci
January 2025
Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Background/purpose: Tubular occlusion is an effective method to treat dentin hypersensitivity. This study aimed to determine the effect of a modified methyl methacrylate-p-styrene sulfonic acid copolymer-based gel desensitizer on dentin permeability and tubule occlusion in extracted human premolars.
Materials And Methods: Hydraulic conductance (HC) measurement (n = 50) and scanning electron microscopy (SEM; n = 64) were performed.
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