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The decline in the clinical relevance of pilocarpine and physostigmine monitored in pharmacology textbooks from 1878 to 2023: nine take-home messages for future (pharmacology) textbook authors.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover, 30625, Germany.
In a recent study, using hydrogen cyanide as paradigm, we have shown that pharmacological knowledge evolves non-linearly ( https://pubmed.ncbi.nlm.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how intramuscular injections of two drugs, physostigmine and neostigmine, affect Na,K-ATPase activity in rat red blood cells after intense exercise.
- Both drugs help reduce stress responses by lowering indicators such as adrenal ascorbic acid, stress-related red blood cell increases, and lipid peroxidation (LPO) markers.
- The drugs appear to restore Na,K-ATPase activity affected by stress and can correct the functions of cholinergic systems in the body’s stress response mechanisms.
Incidence of Adverse Events Using Flumazenil in Patients With Iatrogenic Benzodiazepine Delirium: A Retrospective Study.
Am J Ther
July 2024
Division of Medical Toxicology, Emergency Departement, Virginia Commonwealth University, Richmond, VA.
Background: Flumazenil is a competitive benzodiazepine (BZD) antagonist most used for treating delirium in BZD overdoses. Since its introduction, many have expressed concerns about its safety secondary to the risk of inducing BZD withdrawal and refractory seizures.
Study Question: What is the incidence of adverse drug events after the administration of flumazenil in patients with suspected iatrogenic BZD delirium?
Study Design: This is a retrospective cross-sectional study of patients from a single center from 2010 to 2013.
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration.
Nat Prod Bioprospect
June 2024
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Suipacha 531, 2000, Rosario, Argentina.
The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thiocyanate as a source of bioactive compounds is described. The impact of the reaction on the chemical composition of the mixtures was qualitatively demonstrated through GC-MS, utilizing univariate and multivariate analysis. The reaction transformed most of the components in the natural mixtures, thereby expanding the chemical diversity of the mixtures.
View Article and Find Full Text PDFPhotoinduced radical cascade domino Heck coupling of -aryl acrylamide with vinyl arenes enabled by palladium catalysis.
Chem Commun (Camb)
August 2023
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Chang-zhou University, Changzhou, 213164, China.
Here, a redox-neutral palladium-catalyzed photo-induced radical cascade domino Heck reaction of -aryl acrylamide with vinyl arenes is described. A diverse range of bioactive oxindoles, featuring an all-carbon quaternary center, were synthesized. The reaction is proposed to proceed an open-shell intermediate and occurs under mild reaction conditions, exhibiting excellent functional group tolerance.
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