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Ultrasound-Responsive Hydrogel Incorporated with TGF-β Mimetic Peptides for Endometrium Recovery to Restore Fertility.
ACS Appl Mater Interfaces
October 2024
Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China.
Article Synopsis
- * Researchers developed an ultrasound-responsive hydrogel that contains a TGF-β mimetic peptide to improve the restoration of the endometrium following injury, demonstrating enhanced tissue penetration and cell migration when stimulated by ultrasound.
- * Studies in rats and human uterine tissue showed that this hydrogel could significantly improve recovery from endometrial injury and restore fertility, offering a new method to enhance pregnancy outcomes for women with such injuries.
A New TGF-β Mimetic, XEP™-716 Miniprotein™, Exhibiting Regenerative Properties Objectivized by Instrumental Evaluation.
Dermatol Ther (Heidelb)
November 2024
Activen, Lausanne, Switzerland.
Introduction: Skin aging, which results from intrinsic and extrinsic factors, is characterized by a rough, uneven and wrinkled appearance of the skin at the macroscopic level. At the microscopic level, aging shows lowered keratinocyte turnover, flattened dermal-epidermal junction and reduced collagen fiber density; however, use of skin biopsies to evaluate characteristic properties of these microscopic changes is too limiting for panelists and rarely used. The development of non-invasive techniques is an opportunity to be considered for such evaluations.
View Article and Find Full Text PDFmiRNAs as Modern Biomarkers in Asthma Therapy.
Int J Mol Sci
July 2023
1st Department and Clinic of Paediatrics, Allergology and Cardiology Wrocław Medical University, ul. Chałubińskiego 2a, 50-368 Wrocław, Poland.
Asthma is a chronic inflammatory disease of the airways characterized by shortness of breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 years), miRNAs and their role in asthma have been of constant interest among scientists. These small, non-coding RNA fragments, 18-25 nucleotides long, regulate gene expression at the post-transcriptional level by binding to the target mRNA.
View Article and Find Full Text PDFNeonatal outcomes following prophylactic administration of phenylephrine or noradrenaline in women undergoing scheduled caesarean delivery: A randomised clinical trial.
Eur J Anaesthesiol
March 2022
From the Department of Anesthesia and Intensive Care (AS, KJ, NG), Department of Obstetrics and Gynecology (AA) and Department of Neonatology, PGIMER, Chandigarh, India (PK).
Background: There is limited evidence to support the use of noradrenaline over phenylephrine during elective caesarean section with regards to its impact on foetal acidosis. Concerns regarding a deleterious effect of noradrenaline on foetal blood gas analysis because of its β-mimetic activity cannot currently be ruled out by data from randomised controlled trials.
Objective: We hypothesised that noradrenaline would be associated with higher umbilical artery base excess values and less foetal acidosis compared with phenylephrine.
Vasopressors for the Treatment and Prophylaxis of Spinal Induced Hypotension during Caesarean Section.
Turk J Anaesthesiol Reanim
February 2021
Department of Anaesthesiology and Reanimation, Çukurova University School of Medicine, Adana, Turkey.
Vasopressors have currently become the mainstay therapy for the management of spinal-induced hypotension (SIH) as the major mechanism of hypotension after spinal anaesthesia is the loss of arteriolar tone produced by sympathetic block. Vasopressors for the prophylaxis and treatment of SIH have been the subject of a significant amount of research, yet remain an attractive and important clinical problem. This review will highlight controversies and recent research on the use of vasopressors for both prophylaxis and treatment of SIH.
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