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ASSESSMENT OF SEVERITY OF CHRONIC KIDNEY DISEASE AMONG STEADY STATE HBSS AND HBSC HOMOZYGOUS PATIENTS ATTENDING A TERTIARY HEALTH CARE INSTITUTION IN NORTHERN NIGERIA.
West Afr J Med
November 2024
Department of Medicine, ABUTH, Zaria.
Background: Chronic Kidney Disease (CKD) among patients with Sickle Cell Disease (SCD) notably HbSS and HbSC are increasingly being recognized due to improved health care a comparative severity of CKD among these subgroups is not known in ABUTH Zaria.
Objective: This study was to assess the severity of kidney function among stable patients with HbSS and HbSC in ABUTH, Zaria.
Method: A cross-sectional descriptive study involving steady state 188 HbSS and 22 HbSC attending Haematology Clinic in ABUTH Zaria.
Conservative management of segmental testicular infarction in a patient with sickle cell anemia: A case report.
Urol Case Rep
September 2024
Mayo Clinic Florida, Department of Urology, Jacksonville, FL, USA.
Vaso-occlusive crisis is a sequela of sickle cell disease that can lead to severe pain and infarction at the location of occlusion. In men, genitourinary complications include priapism, hematuria, and very rarely, testicular infarction. Few cases have been previously reported in the literature, but in all of those cases, partial or complete orchiectomy was performed.
View Article and Find Full Text PDFThe Not-So-Benign Sickle Cell Trait: A Case of Renal Medullary Carcinoma.
J Community Hosp Intern Med Perspect
May 2024
Greater Baltimore Medical Center, Towson, MD, USA.
Sickle cell trait (SCT) has long been considered a benign carrier state with malarial protection, but carriers can be affected by increased venous thromboembolism, exercise-related injury, renal complications and very rarely a fatal renal malignancy. Renal medullary carcinoma is a very rare and aggressive renal tumor described almost exclusively in sickle cell trait. A review of the current literature provides clues to this link and describes trends expected in these cases.
View Article and Find Full Text PDFClinical Characteristics, Management, and Outcomes of Patients with Renal Medullary Carcinoma: A Single-center Retrospective Analysis of 135 Patients.
Eur Urol Oncol
July 2024
Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
Background And Objective: SMARCB1-deficient renal medullary carcinoma (RMC) is a rare kidney cancer associated with sickle cell hemoglobinopathies with poor outcomes described only in case reports and small series. We report disease and management characteristics as well as contemporary survival outcomes in a large cohort of patients with RMC.
Methods: Data were extracted retrospectively from all patients with RMC treated at MD Anderson Cancer Center between January 2003 and December 2023.
Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda.
Am J Physiol Renal Physiol
August 2024
Global Health Uganda Research Collaboration, Kampala, Uganda.
A growing body of research is categorizing sex differences in both sickle cell anemia (SCA) and acute kidney injury (AKI); however, most of this work is being conducted in high-resource settings. Here, we evaluated risk factors and clinical parameters associated with AKI and AKI severity, stratified by sex, in a cohort of children hospitalized with SCA and vaso-occlusive pain crisis (VOC). The purpose of this study was to explore sex disparities in a high-risk, vulnerable population.
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