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Application of immunocapture and nanoflow LC-MS/MS to overcome the barriers to the quantitation of oxytocin in plasma of women in third stage labour.
Br J Clin Pharmacol
October 2024
Drug Delivery Disposition and Dynamics, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.
Aims: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. To prevent PPH, the WHO recommends administration of oxytocin (OT) immediately after birth, i.e.
View Article and Find Full Text PDFStudy of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models.
Physiol Behav
September 2024
Institute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, Szeged, Hungary.
Environmental exposures may have endocrine disruptor (ED) effects, e.g., a role for halogenated hydrocarbon chlorobenzenes in increasing vasopressin (AVP), oxytocin (OT) secretion and, in association, anxiety and aggression in male rats has been shown.
View Article and Find Full Text PDFA fit-for-purpose validation of a commercial radioimmunoassay for measurement of human peripheral oxytocin.
Biochem Biophys Rep
July 2024
Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI, 53715, USA.
Oxytocin (OT) is a peptide hormone synthesized in the hypothalamus and released into systemic circulation or other areas of the brain. Its physiological roles include action as a hormone with stimulation of uterine contractions and that as a neuromodulator with involvement in social behaviors and regulation of mood. Its small size and low levels within biological matrices make it challenging to accurately measure.
View Article and Find Full Text PDFHow does it feel? An exploration of neurobiological and clinical correlates of alexithymia in trauma-exposed police-officers with and without PTSD.
Eur J Psychotraumatol
January 2024
Department of Psychiatry, Amsterdam Neuroscience, Amsterdam Public Health, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Alexithymia, an inability to recognise one's emotions, has been associated with trauma-exposure and posttraumatic stress disorder (PTSD). Previous research suggests involvement of the oxytocin system, and socio-emotional neural processes. However, the paucity of neurobiological research on alexithymia, particularly in trauma-exposed populations, warrants further investigation.
View Article and Find Full Text PDFVariable Levels of Oxytocin During Sepsis: The Role of Oxytocin in Sepsis Pathophysiology.
J Intensive Care Med
November 2023
Department of Clinical Pharmacy, School of Pharmacy-International Campus, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.
Background: Although the role of oxytocin in the pathophysiology of sepsis is still unknown, rising preclinical evidence suggests that oxytocin is possibly involved. However, no direct clinical studies have measured the levels of oxytocin during sepsis. In this preliminary study, the serum oxytocin levels were evaluated throughout the duration of sepsis.
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