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A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates.
Mar Drugs
December 2024
Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278-8510, Japan.
Leishmaniasis is a major public health problem, especially affecting vulnerable populations in tropical and subtropical regions. The disease is endemic in 90 countries, and with millions of people at risk, it is seen as one of the ten most neglected tropical diseases. Current treatments face challenges such as high toxicity, side effects, cost, and growing drug resistance.
View Article and Find Full Text PDFFormulation, Characterization and in vitro Release of Topical Nanoemulsion Containing Prednisolone-Derived Corticosteroid.
Drug Dev Ind Pharm
January 2025
Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Izmir, Turkey.
Backround: Prednisolone-Derived Corticosteroid (PDC), has anti-inflammatory activity in ocular administration. However, drug administration to the eye is extremely difficult due to the complex structure of the eye. Because of the ability of the eye to retain the drug and its physiology, the bioavailability of drugs applied to the eye is very low.
View Article and Find Full Text PDFAntifungal potential of silver nanoparticles stabilized with the flavonoid naringenin.
J Med Microbiol
January 2025
Medical Mycology Laboratory, Department of Clinical Analysis and Biomedicine, State University of Maring, Colombo Avenue, 5790, Maring, PR, Brazil.
Fungal infections caused by yeast have increased in recent decades, becoming a major threat to public health. Antifungal therapy represents a challenging problem because, in addition to presenting many side effects, fungal resistance has been increasing in recent years. As a result, the search for new therapeutic agents has advanced with the use of new technologies such as nanoparticles (NPs).
View Article and Find Full Text PDFA Streamlined High-Throughput LC-MS Assay for Quantifying Peptide Degradation in Cell Culture.
J Biomed Mater Res A
January 2025
Department of Bioengineering, Lehigh University, Bethlehem, Pennsylvania, USA.
Peptides are widely used in biomaterials due to their ease of synthesis, ability to signal cells, and modify the properties of biomaterials. A key benefit of using peptides is that they are natural substrates for cell-secreted enzymes, which creates the possibility of utilizing cell-secreted enzymes for tuning cell-material interactions. However, these enzymes can also induce unwanted degradation of bioactive peptides in biomaterials, or in peptide therapies.
View Article and Find Full Text PDFAliens Among Us: Sensitivity of the Invasive Alien Fish Black Bullhead as a Bioindicator of Pollution and Its Safety for Human Consumption.
Toxics
November 2024
Department of Biology and Inland Waters Protection, Institute for Multidisciplinary Research, University of Belgrade, 11030 Belgrade, Serbia.
This study aims to evaluate the black bullhead , an invasive alien fish (IAF) in Serbia, as a bioindicator organism and assess the safety of natural and aquaculture specimens for human consumption. A set of biomarkers was analysed to assess the bioindicator potential at a site exposed to agricultural activities. The genotoxic response was determined by an alkaline comet assay and micronucleus assay in fish erythrocytes, and the metal pollution index (MPI) was calculated to assess the toxic element burden on fish.
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