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The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy.
Front Immunol
October 2022
Department of Urology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Article Synopsis
- Uremic neuropathy in children is a serious problem affecting their nerves and overall health due to kidney issues.
- It's often identified only after treatment like dialysis improves the child's symptoms because there's no specific test for it.
- Researchers are exploring new ways to treat it, focusing on the body's immune response and reducing inflammation, rather than just kidney treatments.
Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling.
Front Immunol
February 2022
Department of Nephrology and Internal Intensive Care Medicine, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
Abstract: Systemic chronic microinflammation and altered cytokine signaling, with adjunct cardiovascular disease (CVD), endothelial maladaptation and dysfunction is common in dialysis patients suffering from end-stage renal disease and associated with increased morbidity and mortality. New hemodialysis filters might offer improvements. We here studied the impact of novel improved molecular cut-off hemodialysis filters on systemic microinflammation, uremia and endothelial dysfunction.
View Article and Find Full Text PDFRecurrent Positivity of SARS-CoV-2 RNA in a Clinically Recovered COVID-19 Patient with End Stage Renal Disease: A Case Report.
JNMA J Nepal Med Assoc
November 2020
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal.
Recurrent or persistent positivity of SARS-CoV-2 RNA in clinically recovered COVID-19 patients have been reported worldwide. However, replication competent live viruses were not recovered beyond two to three weeks from onset of symptoms in mild to severe cases of COVID-19. End stage renal disease is characterized by uremia induced immune dysfunction that increases the risk of infectious diseases including COVID-19.
View Article and Find Full Text PDFEvaluation of biochemical profile of Chronic Kidney Disease of uncertain etiology in Sri Lanka.
PLoS One
July 2020
Transplant and Dialysis Unit, Teaching Hospital, Kandy, Sri Lanka.
Chronic Kidney Disease of uncertain etiology (CKDu) is an endemic, disease that mostly affects young agricultural workers in the rural dry zone of Sri Lanka. This study was designed to identify specific biochemical manifestations of CKDu cases. All (119) non-dialysis definite CKDu patients in Girandurukotte and Wilgamuwa were selected.
View Article and Find Full Text PDFHistopathological and proteomic analyses identify integrin-β1 as a potential mediator of phlebosclerosis in uremic patients.
Clin Exp Nephrol
September 2019
Center for Nephrology and Metabolomics and Division of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Background: Patients with uremia have an excessive mortality from cardiovascular disease (CVD). Arterial remodeling is mainly responsible for uremia-induced CVD and has been well studied, yet venous remodeling is poorly understood. Here we investigate the histopathology and proteomic profiles of venous remodeling in uremic patients.
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