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Dithiocarbamate-Based Sequence-Defined Oligomers as Promising Membrane-Disrupting Antibacterial Agents: Design, Activity, and Mechanism.
ACS Appl Bio Mater
January 2025
Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala 678623, India.
The emerging prevalence of antimicrobial resistance demands cutting-edge therapeutic agents to treat bacterial infections. We present a synthetic strategy to construct sequence-defined oligomers (SDOs) by using dithiocarbamate (DTC). The antibacterial activity of the synthesized library of SDOs was studied using a Gram-positive and a Gram-negative .
View Article and Find Full Text PDFA spiking neural network for active efficient coding.
Front Robot AI
January 2025
Life- and Neurosciences, Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany.
Biological vision systems simultaneously learn to efficiently encode their visual inputs and to control the movements of their eyes based on the visual input they sample. This autonomous joint learning of visual representations and actions has previously been modeled in the Active Efficient Coding (AEC) framework and implemented using traditional frame-based cameras. However, modern event-based cameras are inspired by the retina and offer advantages in terms of acquisition rate, dynamic range, and power consumption.
View Article and Find Full Text PDFA targeted and synergetic nano-delivery system against infection for promoting wound healing.
Mater Today Bio
April 2025
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan Province, China.
Purpose: infection is the most common pathogen in burn wound infections, causing delayed wound healing and progression to chronic wounds. Therefore, there is an urgent need to develop antimicrobial agents that can promote wound healing for effectively treating infected wounds.
Patients And Methods: Using magnetic stirring and ultrasound to synthesize Apt-pM@UCNPmSiO-Cur-CAZ.
Therapeutic benefits of glycerol in dry eye disease.
Front Med (Lausanne)
January 2025
Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Dry eye disease (DED) is one of the most commonly diagnosed eye disorders, with a prevalence ranging from 5 to 50%, depending on the geographic location. DED is a multifactorial disorder of the tears and ocular surface, which results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is also accompanied by increased osmolarity of the tear film and inflammation of the surface of the eye.
View Article and Find Full Text PDFA scoping review and expert consensus on digital determinants of health.
Bull World Health Organ
February 2025
LSE Health, Department of Health Policy, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, London, England.
Objective: To map how social, commercial, political and digital determinants of health have changed or emerged during the recent digital transformation of society and to identify priority areas for policy action.
Methods: We systematically searched MEDLINE, Embase and Web of Science on 24 September 2023, to identify eligible reviews published in 2018 and later. To ensure we included the most recent literature, we supplemented our review with non-systematic searches in PubMed® and Google Scholar, along with records identified by subject matter experts.
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