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Malate initiates a proton-sensing pathway essential for pH regulation of inflammation.
Signal Transduct Target Ther
December 2024
Department of Orthopedic Surgery/Sports Medicine Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
Metabolites can double as a signaling modality that initiates physiological adaptations. Metabolism, a chemical language encoding biological information, has been recognized as a powerful principle directing inflammatory responses. Cytosolic pH is a regulator of inflammatory response in macrophages.
View Article and Find Full Text PDFA high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
Nat Commun
December 2024
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8577, Japan.
Protein is essential for all living organisms; however, excessive protein intake can have adverse effects, such as hyperammonemia. Although mechanisms responding to protein deficiency are well-studied, there is a significant gap in our understanding of how organisms adaptively suppress excessive protein intake. In the present study, utilizing the fruit fly, Drosophila melanogaster, we discover that the peptide hormone CCHamide1 (CCHa1), secreted by enteroendocrine cells in response to a high-protein diet (HPD), is vital for suppressing overconsumption of protein.
View Article and Find Full Text PDFIntensification of future subsurface marine heatwaves in an eddy-resolving model.
Nat Commun
December 2024
Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Physical Oceanography, Ministry of Education, the College of Oceanic and Atmospheric Sciences, Ocean University of China, and Laoshan Laboratory, Qingdao, China.
A shift in depth range enables marine organisms to adapt to marine heatwaves (MHWs). Subsurface MHWs could limit this pathway, yet their response to climate warming remains unclear. Here, using an eddy-resolving Earth system model forced under a high emission scenario, we project a robust global increase in subsurface MHWs driven by rising subsurface mean temperatures and enhanced temperature variability.
View Article and Find Full Text PDFWomen show enhanced proprioceptive target estimation through visual-proprioceptive conflict resolution.
Front Psychol
December 2024
Departamento de Psicologia, Laboratório de Neurociência do Comportamento, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
To form a unified and coherent perception of the organism's state and its relationship with the surrounding environment, the nervous system combines information from various sensory modalities through multisensory integration processes. Occasionally, data from two or more sensory channels may provide conflicting information. This is particularly evident in experiments using the mirror-guided drawing task and the mirror-box illusion, where there is conflict between positional estimates guided by vision and proprioception.
View Article and Find Full Text PDFPredicting kidney graft function and failure among kidney transplant recipients.
BMC Med Res Methodol
December 2024
Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: Graft loss is a major health concern for kidney transplant (KTx) recipients. It is of clinical interest to develop a prognostic model for both graft function, quantified by estimated glomerular filtration rate (eGFR), and the risk of graft failure. Additionally, the model should be dynamic in the sense that it adapts to accumulating longitudinal information, including time-varying at-risk population, predictor-outcome association, and clinical history.
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