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Peptide-Bound Glycative, AGE and Oxidative Modifications as Biomarkers for the Diagnosis of Alzheimer's Disease-A Feasibility Study.
Biomedicines
September 2024
Clinic for Cardiac Surgery, University Medicine Halle, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
The diagnosis of Alzheimer's disease (AD) relies on core cerebrospinal fluid (CSF) biomarkers, amyloid beta (Aβ) and tau. As the brain is then already damaged, researchers still strive to discover earlier biomarkers of disease onset and the progression of AD. Glycation, advanced glycation end products (AGEs) and oxidative modifications on proteins in CSF mirror the underlying biological mechanisms that contribute to early AD pathology.
View Article and Find Full Text PDFMetabolization of Free and Peptide-Bound Oxidized Methionine Derivatives by in a Model System.
J Agric Food Chem
August 2024
Institute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstraße 20, 38106 Braunschweig, Germany.
In the brewing process, methionine is a decisive amino acid for (off-)flavor formation. A significant part of methionine is oxidized to methionine sulfoxide (MetSO) in malt. We hypothesized that MetSO and MetSO are metabolized to volatile compounds during yeast fermentation and examined whether the yeast is able to catabolize l-MetSO and l-MetSO in free and dipeptide-bound forms.
View Article and Find Full Text PDFDietary glycation compounds - implications for human health.
Crit Rev Toxicol
September 2024
Department of Toxicology, University of Würzburg, Würzburg, Germany.
The term "glycation compounds" comprises a wide range of structurally diverse compounds that are formed endogenously and in food the Maillard reaction, a chemical reaction between reducing sugars and amino acids. Glycation compounds produced endogenously are considered to contribute to a range of diseases. This has led to the hypothesis that glycation compounds present in food may also cause adverse effects and thus pose a nutritional risk to human health.
View Article and Find Full Text PDFAbsorption of bioactive peptides following collagen hydrolysate intake: a randomized, double-blind crossover study in healthy individuals.
Front Nutr
August 2024
Rousselot BV, Ghent, Belgium.
Background: Collagen hydrolysates (CH) in functional foods and supplements are dietary sources of amino acids (AAs) and di-and tripeptides linked to various health benefits. This study aimed to investigate the single-dose bioavailability of skin- and hide-derived CH from fish, porcine and bovine origin with different molecular weights (bovine 2,000 and 5,000 Da).
Methods: A randomized, double-blind crossover clinical study was performed with healthy volunteers assessing the plasma concentration of free and peptide-bound hydroxyproline (Hyp) as well as selected peptides reported to be abundantly present in collagen.
Maximizing the Therapeutic Effect of Endothelin Receptor Antagonists in Pulmonary Fibrosis: A Paradigm for Treating the Disease.
Int J Mol Sci
April 2024
School of Pharmacy and Health Sciences, Queens, NY 11439, USA.
Article Synopsis
- Research shows that endothelin-1 (ET-1) may control the influx of inflammatory cells in acute lung injury, suggesting potential treatment strategies with HJP272, an endothelin receptor antagonist.
- In hamster models of pulmonary fibrosis, HJP272 was effective in reducing inflammation when administered before injury, but not afterward, indicating timing is crucial for its effectiveness.
- The study proposes developing a biomarker for early lung changes, specifically the ratio of free to peptide-bound desmosine, to enhance the use of endothelin receptor antagonists and other therapies in preventing disease progression.
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