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Posttranslational modifications in cardiac metabolic remodeling mediated by metabolites: Implications for disease pathology and therapeutic potential.
Metabolism
January 2025
Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Chang-Le Xi Street #127, Xi' an 710032, China. Electronic address:
The nonenergy-producing or biomass-accumulating functions of metabolism are attracting increasing attention, as metabolic changes are gaining importance as discrete signaling pathways in modulating enzyme activity and gene expression. Substantial evidence suggests that myocardial metabolic remodeling occurring during diabetic cardiomyopathy, heart failure, and cardiac pathological stress (e.g.
View Article and Find Full Text PDFEffects of aromatherapy on the overload and fatigue of informal elderly caregivers: a pilot study.
Rev Gaucha Enferm
December 2024
Universidade de São Paulo. Escola de Enfermagem. São Paulo, São Paulo, Brasil.
Objective: To verify the effect of aromatherapy (inhaled or via the skin) with lavender, sweet orange and bergamot essential oils on caregivers' overload and fatigue.
Method: Pilot, quasi-experimental, randomized, non-blind and parallel study with two groups. The reduced Zarit Burden Interview and Revised Piper scales were used, comparing the effect of two routes of administration.
Iron-responsive nanoparticle-loaded bilayer dissolving microneedles for selective and controlled transdermal delivery of deferasirox in β-thalassemia major treatment.
Colloids Surf B Biointerfaces
March 2025
Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia.
Article Synopsis
- * To improve DFX delivery, researchers developed iron-responsive nanoparticles incorporated into dissolving microneedles for transdermal application, ensuring targeted drug release in the presence of iron.
- * Laboratory tests showed that these microneedles effectively penetrated skin layers and facilitated high iron-selective DFX delivery in rat models, outperforming traditional oral administration.
Porphyria Cutanea Tarda in a Patient With Hereditary Hemochromatosis: A Complex Overlap Disorder.
Cureus
November 2024
Division of Hematology and Oncology, Sidney Health Center Cancer Care, Sidney, USA.
We present a case of a 34-year-old woman with a 12-week history of blistering skin lesions, ultimately diagnosed with co-existing porphyria cutanea tarda (PCT) and hereditary hemochromatosis (HH) due to a homozygous C282Y mutation. The patient's discovered genetic predisposition to iron overload played a key role in the development of clinically symptomatic PCT. Treatment with serial therapeutic phlebotomy was started, dramatically improving her symptomatic cutaneous disease, iron indices, and liver function tests.
View Article and Find Full Text PDF[Endogenous skin overloads].
Ann Pathol
November 2024
Département de Pathologie, université Paris Est Créteil (UPEC), hôpital Henri-Mondor, AP-HP, 1, rue Gustave Eiffel, 94000 Créteil, France. Electronic address:
Article Synopsis
- * Some skin lesions can be subtle, often categorized as "invisible" dermatoses, like primary macular cutaneous amyloidosis and calciphylaxis, necessitating detailed examination.
- * Certain conditions have significant prognostic implications, indicating potential underlying diseases like monoclonal gammopathies or association with visceral damage, underscoring the importance of clinical-pathological comparison to differentiate between serious conditions.
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