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[Clinical analysis of 6 cases of induced rash and mucositis in children].

Zhonghua Er Ke Za Zhi

February 2025

Department of Gastroenterology and Infectious Diseases, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China.

To summarize the clinical features, laboratory findings, treatment and prognosis of children confirmed as -induced rash and mucositis (MIRM) in children. This retrospective study concluded 6 children diagnosed as MIRM in Department of Gastroenterology and Infectious Diseases, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University from August 2023 to April 2024. This paper described the characteristics of MIRM and analyzed the therapeutic strategy and prognosis.

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Article Synopsis
  • A 44-year-old woman was misdiagnosed with pigmented purpura due to a unique skin condition on her thumb that lacked itchiness and typical features of classical mycosis fungoides (MF).* -
  • After thorough testing and evaluation, the condition was identified as cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides, which is uncommon and typically seen in middle-aged individuals.* -
  • The case highlights the importance of accurate diagnosis in rare skin disorders, as the patient's treatment involved steroid and UV therapy, emphasizing the need for awareness and further research to improve outcomes.*
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Retiform purpura-like lesions are rarely seen clinically and can be induced by cutaneous vascular wall damage or a lumen-occlusive disease arising from a broad range of triggers, including infection, drugs, emboli, cryoglobulinemia, disseminated intravascular coagulation, and autoimmune disease. Here, we present the case of a patient suffering from both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), with retiform purpura as the first lesion and lacking other typical symptoms of SLE, such as photosensitivity, malar rash, ulceration of the mouth and nose, alopecia, and joint pain.

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Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis.

Acta Dermatovenerol Croat

September 2022

Aleksandra Frątczak MD, Department of Dermatology, Medical University of Silesia, School of Medicine in Katowice, 20/24 Francuska St., 40-027 Katowice, Poland;

Torasemide is a loop diuretic with a molecule that is chemically similar to the sulphonamides described as eosinophilic granulomatosis with polyangiitis (EGPA) triggering drugs. The presented case is probably the first description of torasemide-induced vascular purpura in the course of EGPA. Any diagnosis of vasculitis should be followed by an identification of drugs that may aggravate the disease.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the etiologic agent of coronavirus disease 2019 (COVID-19), causes an excessive inflammatory response and hemostatic abnormalities in the lungs, kidney, and skin. Four patients with COVID-19 admitted to an acute care community hospital developed nonblanchable purpuric macules, patches, and retiform purpura-like lesions at the sacrum, buttocks, lower extremities, and upper back. These lesions can be misdiagnosed as deep tissue pressure injuries.

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