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The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury.
Inflamm Res
January 2025
Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Background: Hyperoxia-induced brain injury is a severe neurological complication that is often accompanied by adverse long-term prognosis. The pathogenesis of hyperoxia-induced brain injury is highly complex, with neuroinflammation playing a crucial role. The activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which plays a pivotal role in regulating and amplifying the inflammatory response, is the pathological core of hyperoxia-induced brain injury.
View Article and Find Full Text PDFSingle, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia.
Respir Res
January 2025
Chiesi Farmaceutici, R&D Department, Parma, Italy.
Background: Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity of the strong hyperoxic hit precludes a longer-term follow-up due to high mortality after the first week of life.
View Article and Find Full Text PDFRecovery from pulmonary oxygen toxicity: a new (ESOT) model.
Undersea Hyperb Med
January 2025
Hyperbaric and Tissue Viability Unit, Gozo General Hospital, Malta.
Arieli has previously demonstrated that the exposure metric K could be used to predict pulmonary oxygen toxicity (POT) based on changes in Vital Capacity (VC). Our previous findings indicate that the Equivalent Surface Oxygen Time (ESOT) allows the estimation of POT without loss of accuracy compared to K. In this work, we have further investigated POT recovery.
View Article and Find Full Text PDFAcute selective serotonin-reuptake inhibition elevates basal ventilation, attenuates the rebreathing ventilatory response, independent of cerebral perfusion.
J Appl Physiol (1985)
January 2025
Centre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, Kelowna, BC, Canada.
Serotonin (5-HT) is integral to signalling in areas of the brainstem controlling ventilation and is involved in central chemoreception. Selective serotonin reuptake inhibitors (SSRIs), used to effectively increase 5-HT concentrations, are commonly prescribed for depression. The effects of SSRIs on the control of breathing and the potential influence of cerebral blood flow (CBF) have not been directly assessed.
View Article and Find Full Text PDFDevelopment of myopia in scuba diving and hyperbaric oxygen treatment: a case report and systematic review.
Diving Hyperb Med
December 2024
Department of Pathology, Helsinki University, Helsinki, Finland.
Introduction: A 54-year-old, previously healthy Caucasian male diver was on a 22-day liveaboard diving holiday. During this time, he performed 75 open-circuit dives, of which 72 were with enriched air nitrox. All dives were within recreational length and depth.
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