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Structure of coxsackievirus cloverleaf RNA and 3C dimer establishes the RNA-binding mechanism of enterovirus protease 3C.
Sci Adv
March 2025
Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.
In positive-strand RNA viruses, the genome serves as a template for both protein translation and negative-strand RNA synthesis. Enteroviruses use the cloverleaf RNA structure at the 5' end of the genome to balance these two processes. Cloverleaf acts as a promoter for RNA synthesis and forms a complex with viral 3CD protein, the precursor to 3C protease, and 3D polymerase.
View Article and Find Full Text PDFThe DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.
Cell Mol Life Sci
March 2025
Institute for Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany.
Signal peptide peptidase (SPP) is an ER-resident aspartyl intramembrane protease cleaving proteins within type II-oriented transmembrane segments. Here, we identified the tail-anchored protein Three prime repair exonuclease 1 (TREX1) as a novel substrate of SPP. Based on its DNase activity, TREX1 removes cytosolic DNA acting as a negative regulator of the DNA-sensing cGAS/STING pathway.
View Article and Find Full Text PDFCaki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity.
Cells
February 2025
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Lipotoxicity, resulting from the buildup of excess lipids in non-adipose tissues, is increasingly recognized as a major contributor to the progression of kidney disease, highlighting the need for alternative models to assess its effects on renal cells. The main aim of this study was to investigate the usefulness of Caki-1, a human proximal tubule (PT) and renal cell carcinoma (RCC) representative cell line, as a 3D model system for studying free fatty acid-induced PT lipotoxicity. Caki-1 spheroids were generated and maintained on ultra-low attachment plates and characterized regarding time-dependent morphology changes.
View Article and Find Full Text PDFAnti-listeria activity of newly isolated lactic acid bacteria from fermented foods and their application to smoked salmon(Coho).
Int J Food Microbiol
March 2025
Department of Food Science and Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546, Republic of Korea; GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, Gyeonggi 17546, Republic of Korea. Electronic address:
The objective of this study was to evaluate the anti-listeria activities of lactic acid bacteria (LAB) isolated from Korean fermented foods and to assess the effect of fermentate (cells and cell-free supernatant [CFS]), CFS or cells in controlling L. monocytogenes on smoked salmon, packaged either in vacuum- and air-packaging. One L.
View Article and Find Full Text PDFScreening of Angiotensin-I Converting Enzyme (ACE) Inhibitory Peptides from Thermolytic Hydrolysate of Arthrospira platensis.
Mar Biotechnol (NY)
March 2025
Department of Biological Science and Technology, National Pingtung University of Science and Technology, 1, Hseuh-Fu Road, Nei-Pu, Pingtung, 91201, Taiwan (ROC).
Angiotensin-I Converting Enzyme (ACE, EC 3.4.15.
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