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The role of cGAS-STING pathway in the development of radiation-induced lung injury.
J Cancer Res Clin Oncol
January 2025
Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Background And Purpose: Radiation-induced lung injury (RILI) limits the efficacy of thoracic radiotherapy. However, the underlying mechanism of RILI remains unclear. cGAS-STING pathway is reported to be involved in the recognization of cytosolic dsDNA and various inflammatory diseases.
View Article and Find Full Text PDFEffects of ionizing radiation on osteoblastic cells: In vitro insights into the etiopathogenesis of osteoradionecrosis.
Arch Oral Biol
December 2024
University of Brasília, Brasília, Laboratory of Oral Histopathology, Health Sciences Faculty, Brazil. Electronic address:
Objective: This in vitro study aimed to analyze the effects of ionizing radiation on immortalized human osteoblast-like cells (SaOS-2) and further assess their cellular response in co-culture with fibroblasts. These analyses, conducted in both monoculture and co-culture, are based on two theoretical models of osteoradionecrosis - the theory of hypoxia and cellular necrosis and the theory of the radiation-induced fibroatrophic process.
Design: SaOS-2 cells were exposed to ionizing radiation and evaluated for cell viability, nitric oxide (NO) production, cellular morphology, wound healing, and gene expression related to the PI3K-AKT-mTOR pathway.
Temperature dynamics and mechanical properties analysis of carbon fiber epoxy composites radiated by nuclear explosion simulated light source.
Sci Rep
January 2025
Engineering Research Center of Flexible Radiation Protection Technology, Universities of Shaanxi Province, Xi'an Polytechnic University, Xi'an, 710048, Shaanxi, China.
The impact of light radiation, a predominant energy release mechanism in nuclear explosions, on material properties is of critical importance. This investigation employed an artificial light source to replicate the effects of nuclear explosion radiation and utilized a physical information neural network (PINN) to examine the temperature evolution and corresponding changes in the mechanical properties of carbon fiber/epoxy composites (CFEC). A light source simulating nuclear explosion's light radiation was built to irradiate the CFEC, then measure the reflection spectrum and temperature of samples.
View Article and Find Full Text PDFA novel mouse model of image-guided radiation-induced acute kidney injury using SARRP.
Biochem Biophys Res Commun
January 2025
Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences, Seoul, South Korea. Electronic address:
Radiation therapy is crucial for cancer treatment, but it often causes tissue damage. The kidney, which is sensitive to radiation, is under-researched in this context. This study aimed to develop a mouse model for radiation-induced acute kidney injury (AKI) using a small animal radiation research platform (SARRP) to mimic clinical radiation conditions.
View Article and Find Full Text PDFX-ray irradiation reduces ATP-dependent activation of NLRP3 inflammasome by inhibiting TWIK2 activity in macrophages.
Immunol Lett
December 2024
Department of Emergency, Affiliated Hospital of Zunyi Medical University, 563003 Zunyi, Guizhou, China. Electronic address:
Background: The spleen, as the body's largest peripheral immune organ and a crucial source of circulating monocytes, plays a significant role in the acute inflammatory response of spleen-derived macrophages to diseases. Therefore, studying the impact and mechanism of X-ray irradiation on spleen-derived macrophages' inflammatory responses is of great importance.
Method: Extracted and identified mice splenic macrophages were divided into four groups: control group, LPS and ATP co-stimulated non-irradiated group, LPS and ATP co-stimulated group irradiated after 6 h, and LPS and ATP co-stimulated group irradiated after 12 h In the LPS and ATP co-stimulated groups, LPS (1μg/ml) and ATP (5mmol/L) were added to establish an inflammatory model in mice splenic macrophages.
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