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Functional analysis of B7-H3 in colonic carcinoma cells.
Asian Pac J Cancer Prev
April 2013
Department of Oncological Surgery, People's Hospital of Zhengzhou, Zhengzhou, China.
B7-H3 is a newly discovered member of the B7/CD28 superfamily which functions as an important T-cell immune molecule. It has been reported recently that B7-H3 is highly expressed in many cancer cells, the data indicating that it may be a regulation factor contributing to tumor-resistance. In our study, we used bioinformatics to identify differentially expressed genes between colonic cancer cells and normal colonic cells, aiming to analyze mechanisms and identify sub-pathways closely related to progression, with the final aim of finding small molecule drugs which might interfere this progression.
View Article and Find Full Text PDFSpectrophotometric determination of Rauwolfia alkaloids: estimation of reserpine in pharmaceuticals.
Anal Sci
March 2004
Analytical Research Laboratory, Department of Chemistry, H. B. Technological Institute, Kanpur-208002, India.
A simple, sensitive and economically viable spectrophotometric method for the determination of some Rauwolfia alkaloids (ajmaline, ajmalicine, reserpine and yohimbine-HCl) has been developed. The method involves the oxidation of Rauwolfia alkaloids by iron(III) and subsequent complexation of iron(II) with 1,10-phenanthroline, forming a red-colored complex having the maximum absorbance at 510 nm. The method is applied to the determination of reserpine in tablets of pharmaceutical formulations.
View Article and Find Full Text PDFDifferential effects of alkaloids on sodium currents of isolated single skeletal muscle fibers.
FEBS Lett
October 1998
II. Physiologisches Institut, Universität Heidelberg, Germany.
The effects of the alkaloids ajmaline, lupanine, sparteine, serpentine, strychnine, and yohimbine were studied with the loose patch clamp technique on sodium currents of isolated single skeletal muscle fibers. The IC50 values for half-maximal blocking of the sodium currents were 6.6 microM for ajmaline, 55.
View Article and Find Full Text PDFEffect of Ajmaloon on the baroreceptor-heart rate reflex in anaesthetized rabbits and monkeys.
Indian J Physiol Pharmacol
April 1995
Department of Physiology, Vallabbhai Patel Chest Institute, University of Delhi.
The effects of a herbal drug, Ajmaloon (Hamdard, India), on the arterial blood pressure, heart rate (HR) and baroreceptor-heart rate reflex were studied in anesthetized rabbits and monkeys. Intravenously administered Ajmaloon produced a dose-dependent hypotensive response in both the species without any significant effect on the heart rate. Only in high doses (200 mg/kg or more).
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