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Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting.
BMC Med
January 2025
Department of Oncology, University of Oxford, Oxford, UK.
Background: The clinical translation of positron emission tomography (PET) radiotracers for cancer management presents complex challenges. We have developed consensus-based recommendations for preclinical and clinical assessment of novel and established radiotracers, applied to image different cancer types, to improve the standardisation of translational methodologies and accelerate clinical implementation.
Methods: A consensus process was developed using the RAND/UCLA Appropriateness Method (RAM) to gather insights from a multidisciplinary panel of 38 key stakeholders on the appropriateness of preclinical and clinical methodologies and stakeholder engagement for PET radiotracer translation.
Behavioral nudges prevent loan delinquencies at scale: A 13-million-person field experiment.
Proc Natl Acad Sci U S A
January 2025
The Harris School of Public Policy, University of Chicago, Chicago, IL 60637.
Americans collectively hold over $1.6 trillion in student loan debt, and over the last decade millions of borrowers have defaulted on loans, with serious consequences for their financial health. In a 13-million-person field experiment with the U.
View Article and Find Full Text PDFA literature-based cost-effectiveness analysis of device-assisted suturing versus needle-driven suturing during laparotomy closure.
Hernia
January 2025
The Swedish Institute for Health Economics, Svartmangatan 18, Stockholm, 111 29, Sweden.
Purpose: Small-bites suturing technique for laparotomy closure is now recommended as the standard of care. However, uptake of the practice remains slow. A medical technology called the SutureTOOL has been developed which can facilitate implementation of small-bites.
View Article and Find Full Text PDFPrimary care in the COVID-19 pandemic and beyond: Lessons from Ontario.
Can Fam Physician
January 2025
Vice-Chair of Quality and Innovation in the DFCM at U of T; Associate Professor in the Faculty of Medicine and the Institute of Health Policy, Management and Evaluation at U of T; Scientist in the MAP Centre for Urban Health Solutions at St Michael's Hospital; and a staff physician in the DFCM at St Michael's Hospital, Unity Health Toronto.
Objective: To understand the role of primary care in the COVID-19 pandemic to provide insight into its functioning and inform potential reforms.
Composition Of The Committee: The now dissolved Ontario COVID-19 Science Advisory Table (Science Table) was formed in July 2020 to provide decision makers and the public with a synthesis of rapidly evolving evidence related to COVID-19. The Science Table was based at the Dalla Lana School of Public Health at the University of Toronto, and supported by Public Health Ontario.
Maternal lipids in overweight and obesity: implications for pregnancy outcomes and offspring's body composition.
Semin Immunopathol
January 2025
Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Overweight and obesity (OWO) are linked to dyslipidemia and low-grade chronic inflammation, which is fueled by lipotoxicity and oxidative stress. In the context of pregnancy, maternal OWO has long been known to negatively impact on pregnancy outcomes and maternal health, as well as to imprint a higher risk for diseases in offspring later in life. Emerging research suggests that individual lipid metabolites, which collectively form the lipidome, may play a causal role in the pathogenesis of OWO-related diseases.
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