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Association of State Cannabis Legalization With Cannabis Use Disorder and Cannabis Poisoning.
JAMA Psychiatry
December 2024
Institute for Biomedical Informatics, College of Medicine, University of Kentucky, Lexington.
Importance: Whether state implementation of medical and recreational cannabis laws is associated with increased cannabis use disorder (CUD) and/or cannabis poisoning among adults is not evident.
Objective: To examine state-level medical and recreational cannabis laws' associations with CUD and cannabis poisoning, overall and by sex and age subgroups.
Design, Setting, And Participants: In this longitudinal cohort study, state-level CUD and cannabis poisoning diagnoses from January 2011 to December 2021 were examined across all 50 US states and the District of Columbia before and after the implementation of medical and recreational cannabis laws (MCLs and RCLs, respectively) using a staggered adoption difference-in-differences approach.
An Evaluation of Medication Adherence in New Tuberculosis Cases in Ankara: A Prospective Cohort Study.
Healthcare (Basel)
November 2024
Department of Public Health, Faculty of Medicine, Hacettepe University, Ankara 06230, Türkiye.
Background/objectives: The objective of this study was to investigate the factors influencing adherence with tuberculosis medication therapy. Non-adherence can result in treatment failure, ongoing infectiousness, and the development of drug resistance. Therefore, understanding the reasons behind non-adherence is crucial for achieving the World Health Organization's target of 90% treatment success.
View Article and Find Full Text PDFGut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin.
Microbiol Spectr
January 2025
Institute of Translational Biomedicine, Saint-Petersburg State University, Saint-Petersburg, Russia.
Unlabelled: Many studies have reported gut microbiome alterations in psoriasis patients, suggesting dysbiosis. While evidence for dysbiosis and its link to pathogenesis remains inconclusive, murine models of psoriasis suggest that gut microbiome alterations develop in response to psoriasis-like inflammation. Hence, the dominant narrative about gut microbiome alterations' impact on disease should be evaluated critically with more data and a well-powered approach.
View Article and Find Full Text PDFArticle Synopsis
- * CHF is a worsening condition with a high chance of death and hospital readmissions, so consistent monitoring and timely therapy adjustments are crucial for improving patient outcomes.
- * The outpatient unit aims to increase the follow-up care for CHF patients through preventive counseling and telemedicine, targeting early detection of those at high risk for disease progression, ultimately enhancing their quality and length of life.
Development and preliminary assessment of the iFIND TBR: all-in- one molecular diagnostic assay for rapid detection of and rifampicin resistance.
Front Cell Infect Microbiol
November 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Introduction: Early and accurate diagnosis of tuberculosis (TB) is crucial for initiating timely treatment and preventing new infections. In this study, we introduced the iFIND TBR assay, an automated all-in-one tuberculosis detection approach that simultaneously detect (MTB) and rifampicin (RIF) resistance.
Methods: The limits of detection (LOD), sensitivity, specificity, and RIF-R rpoB mutation detection of the iFIND TBR were tested on Mycobacterium tuberculosis DNA or sputum samples spiked with known numbers of M.
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