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Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules.
Cell Mol Life Sci
May 2024
Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch Str, 17475, Greifswald, Germany.
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute pancreatitis. However, the exact molecular mechanisms of co-localization are not fully understood. In this study, we investigated the role of lysosomes in the onset of acute pancreatitis by using two different experimental approaches.
View Article and Find Full Text PDFAstaxanthin alleviates oxidative damage in acute pancreatitis via direct antioxidant mechanisms.
Turk J Gastroenterol
October 2020
Department of Medical Laboratory Techniques, Marmara University Vocational School of Health Services, İstanbul, Turkey.
Background/aims: Astaxanthin (ATX) is a naturally occurring carotenoid and a potent antioxidant. Various anti-inflammatory effects of ATX have been examined. We aimed to investigate the protective effect of ATX and its mechanism in a cerulein-induced acute pancreatitis rat model.
View Article and Find Full Text PDFTransgenic Expression of PRSS1 Sensitizes Mice to Pancreatitis.
Gastroenterology
March 2020
Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
Background & Aims: Mutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied the effects of expressing mutant forms of human PRSS1 in mice.
View Article and Find Full Text PDFMultimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.
Gastroenterology
February 2019
Department of Medicine, Mayo Clinic, Scottsdale, Arizona. Electronic address:
Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with the activation of different signaling pathways in pancreatic cells, posing challenges to the development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, could lessen the severity of AP induced by different methods in rats.
Methods: A urethane balloon with 2 polyurethane tubes was placed inside the stomach of rats.
[An Improved Acute Pancreatitis Apoptosis/Necrosis Model of Acinar Cells].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2018
Institute of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective: To improve the apoptosis/necrosis model of ascites-induced acute pancreatitic (AP) acinar cells by using the co-culture system and mixed ascites technology for the first time. Furthermore, we compared this improved model with cerulein and cerulein+LPS models, and observed the effects of three models on acinar apoptotic/necrotic-related indicators.
Methods: The cultured rat acinar cells AR42J were divided in four groups: control group (medium+PBS), cerulein group (medium+10 nmol/L cerulein), cerulein+LPS group (medium+10 nmol/L cerulein+10 mg/L LPS) and improved ascites group.
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